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CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs
Analysis of gene-targeted mice identified the chemokine receptor CCR7 as an important organizer of the primary immune response, and found that lymphocytes and dendritic cells fail to migrate into the draining lymph nodes upon activation, resulting in impaired migration of lymphocytes. Expand
Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production
Chemokines and their receptors have been identified as major regulators controlling the functional organization of secondary lymphoid organs. Here we show that expression of CXC chemokine receptor 5Expand
The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
It is found that characteristic intracellular inclusions of misfolded proteins define C9orf72 pathology, but the core proteins of the majority of inclusions are still unknown, and a new class of proteins links a common genetic mutation to the predominant pathology in certain neurodegenerative diseases. Expand
ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons
It is concluded that ADAM10 is the physiologically relevant, constitutive α‐secretase of APP, and a novel pathway for APP processing is suggested, in which ADAM 10 can partially compete with γ‐secret enzyme for the cleavage of a C‐terminal APP fragment generated by β‐ secretase. Expand
A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen
The results identify the putative chemokine receptor BLR1 as the first G protein-coupled receptor involved in B cell migration and localization of these cells within specific anatomic compartments. Expand
Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1
It is shown that the epigenetic activator Ash1 is a multi-catalytic histone methyl-transferase (HMTase) that methylates lysine residues 4 and 9 in H3 and 20 in H4, which may provide a specific signal for the establishment of epigenetic, active transcription patterns. Expand
Arginine methylation next to the PY‐NLS modulates Transportin binding and nuclear import of FUS
This study shows that arginine methylation modulates nuclear import of FUS via a novel TRN‐binding epitope and provides evidence that these two diseases may be initiated by distinct pathomechanisms and implicates alterations in arginin methylation in pathogenesis. Expand
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
Novel rat monoclonal antibodies raised against phosphorylation of S409/410 of TDP-43 are developed and characterized and will be extremely useful for the neuropathological routine diagnostics of T DP-43 proteinopathies and for the investigation of emerging cellular and animal models for TSPs. Expand
Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7
The results indicate that restriction of serine-7 epitopes to the Linker-proximal region limits CTD phosphorylation patterns and is a requirement for optimal gene expression. Expand
Noncoding RNAs of Trithorax Response Elements Recruit Drosophila Ash1 to Ultrabithorax
Transgenic transcription of TRE transcripts restores recruitment of Ash1 to Ubx TREs and restores Ubx expression in Drosophila cells and tissues that lack endogenous TRE transcripts, which suggests that noncoding TRE transcripts play an important role in epigenetic activation of gene expression. Expand