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cytostatin

National Institutes of Health

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OrganophosphatesPyrones

Papers overview

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2010
2010
Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis
(Cancer Sci 2010; 101: 743–750) 
Highly Cited
2009
Highly Cited
2009
Structure-Activity Relationship Studies of Fostriecin, Cytostatin, and Key Analogs, with PP1, PP2A, PP5, and (β12–β13)-Chimeras (PP1/PP2A and PP5/PP2A), Provide Further Insight into the Inhibitory…
Fostriecin and cytostatin are structurally related natural inhibitors of serine/threonine phosphatases, with promising antitumor… 
2006
2006
Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.
The total synthesis of cytostatin, an antitumor agent belonging to the fostriecin family of natural products, is described in… 
Highly Cited
2004
Highly Cited
2004
Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues.
The total synthesis of the natural product cytostatin is described which inhibits protein phosphatase 2A. Cytostatin has anti… 
Highly Cited
2004
Highly Cited
2004
Protein phosphatase 2A inhibition induces cerebellar long-term depression and declustering of synaptic AMPA receptor.
Phosphorylation of synaptic (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) (AMPA) receptors (AMPARs) is an… 
2003
2003
Specific inhibitors of protein phosphatase 2A inhibit tumor metastasis through augmentation of natural killer cells.
1999
1999
Differential Induction of Apoptosis in B16 Melanoma and EL‐4 Lymphoma Cells by Cytostatin and Bactobolin
Most solid tumor cells are less sensitive to apoptosis induced by anticancer drugs than hematopoietic cancer cells. However, the… 
1995
1995
Inhibitory effect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cells.
Tumorcells may interact with extracellular matrices (ECM) such as laminin, fibronectin and collagen type IV, at a variety of… 
1994
1994
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities.
Cytostatin has been identified as a novel inhibitor of cell adhesion to components of extracellular matrix (ECM) in cultured… 
1994
1994
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. II. Physico-chemical properties and structure determination.
The structure of cytostatin was determined to be 5,6-dihydro-5-methyl-6-(6-hydroxy,1,5-dimethyl-4-phosphonooxy-7,9, 11… 
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