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cytostatin

 
National Institutes of Health

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2 relations

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OrganophosphatesPyrones

Papers overview

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2009
2009
Structure-Activity Relationship Studies of Fostriecin, Cytostatin, and Key Analogs, with PP1, PP2A, PP5, and (β12–β13)-Chimeras (PP1/PP2A and PP5/PP2A), Provide Further Insight into the Inhibitory…
Fostriecin and cytostatin are structurally related natural inhibitors of serine/threonine phosphatases, with promising antitumor… Expand
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2008
2008
Confirmation of the stereostructure of (+)-cytostatin by fluorous mixture synthesis of four candidate stereoisomers.
Mix and match: Four closely related candidate isomers for cytostatin have been synthesized by using the technique of fluorous… Expand
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2006
2006
Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.
The total synthesis of cytostatin, an antitumor agent belonging to the fostriecin family of natural products, is described in… Expand
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2004
2004
Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues.
The total synthesis of the natural product cytostatin is described which inhibits protein phosphatase 2A. Cytostatin has anti… Expand
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Highly Cited
2004
Highly Cited
2004
Protein phosphatase 2A inhibition induces cerebellar long-term depression and declustering of synaptic AMPA receptor.
Phosphorylation of synaptic (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) (AMPA) receptors (AMPARs) is an… Expand
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2003
2003
Synthesis and biological evaluation of cytostatin analogues.
Analogues of the serine/threonine phosphatase 2A inhibitor cytostatin were synthesized and evaluated as inhibitors of various… Expand
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1999
1999
Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A.
Cytostatin, which is isolated from a microbial cultured broth as a low molecular weight inhibitor of cell adhesion to… Expand
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1999
1999
Differential Induction of Apoptosis in B16 Melanoma and EL‐4 Lymphoma Cells by Cytostatin and Bactobolin
Most solid tumor cells are less sensitive to apoptosis induced by anticancer drugs than hematopoietic cancer cells. However, the… Expand
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1994
1994
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities.
Cytostatin has been identified as a novel inhibitor of cell adhesion to components of extracellular matrix (ECM) in cultured… Expand
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1994
1994
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. II. Physico-chemical properties and structure determination.
The structure of cytostatin was determined to be 5,6-dihydro-5-methyl-6-(6-hydroxy,1,5-dimethyl-4-phosphonooxy-7,9, 11… Expand
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