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cyclopropylamine

 
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
Epigenetic dysregulation has emerged as an important mechanism in cancer. Alterations in epigenetic machinery have become a major… Expand
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2015
2015
Cyclopropylamines, inhibitors of monoamine oxidases (MAO) and lysine-specific demethylase (LSD1), provide a useful structural… Expand
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2011
2011
In all organisms, oxidation threatens the integrity of the genome. DNA-mediated charge transport (CT) may play an important role… Expand
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Highly Cited
2010
Highly Cited
2010
LSD1 is a flavin-dependent histone demethylase that oxidatively removes methyl groups from Lys-4 of histone H3. LSD1 belongs to… Expand
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2008
2008
Trovafloxacin (Trovan) is a fluoroquinolone antibiotic drug with a long half-life and broad-spectrum activity. Since its entry… Expand
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Highly Cited
2007
Highly Cited
2007
The catalytic domain of the flavin-dependent human histone demethylase lysine-specific demethylase 1 (LSD1) belongs to the family… Expand
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2007
2007
Lysine-specific demethylase 1 (LSD1) is a transcriptional repressor and a flavin-dependent amine oxidase that is responsible for… Expand
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2006
2006
The suicide substrate activity of N-benzyl-N-cyclopropylamine (1) and N-benzyl-N-(1'-methylcyclopropyl)amine (2) toward… Expand
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2001
2001
Cyclopropylamines inactivate cytochrome P450 enzymes which catalyze their oxidative N-dealkylation. A key intermediate in both… Expand
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1998
1998
A series of four racemic ring-substituted trans-2-(indol-3-yl)cyclopropylamine derivatives was synthesized and tested for… Expand
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