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CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.
TLDR
Results show that CX3CR1-dependent accumulation of subretinal MCs evokes cardinal features of AMD and reveal what the authors believe to be a novel pathogenic process with important implications for the development of new therapies for AMD. Expand
Agonist-independent Nuclear Localization of the Apelin, Angiotensin AT1, and Bradykinin B2 Receptors*
TLDR
The apelin receptor exhibits nuclear localization in human brain; distinct cell-dependent mechanisms for the nuclear transport of apelin, AT1, and B2 receptors; and the disruption of a nuclear localization signal sequence disrupts the nuclear translocation of the apelin receptors. Expand
Formation of Isoprostane-like Compounds (Neuroprostanes) in Vivo from Docosahexaenoic Acid*
TLDR
F4-neuroprostane-containing aminophospholipids might adversely effect neuronal function as a result of alterations they induce in the biophysical properties of neuronal membranes, and may provide a unique marker of oxidative injury to the brain and could potentially exert biological activity. Expand
Potential role of microglia in retinal blood vessel formation.
TLDR
It is suggested that proper retinal blood vessel formation requires an adequate resident microglial population because diminished microglia are associated with decreased vascularity in models of ischemic retinopathy and retinal vascular development. Expand
Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life.
TLDR
Current concepts on retinal microvascular degeneration, neovascularization, and available treatments, as well as present future perspectives toward more profound elucidation of the pathogenesis of ROP are discussed. Expand
Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus.
TLDR
PGE2 dilates the late gestation fetal DA through pathways that involve either cAMP (EP2 and EP4) or K(ATP) channels (EP3), and the loss of EP3 andEP4 receptors in the newborn DA is consistent with its decreased responsiveness to PGE2. Expand
Regulation of eNOS Expression in Brain Endothelial Cells by Perinuclear EP3 Receptors
TLDR
It is described for the first time that PGE2 through its access into cell by prostaglandin transporters induces eNOS expression by activating perinuclear EP3 receptors coupled to pertussis toxin-sensitive G proteins, a process that depends on nuclear envelope KCa channels, protein kinases, and NF-&kgr;B; the roles for nuclear EP3 receptor seem different from those on plasma membrane. Expand
A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway*
TLDR
Findings regarding the allosteric and biased nature of PDC113.824 offer new mechanistic insights into FP receptor signaling relevant to parturition and suggest novel therapeutic opportunities for the development of new tocolytic drugs. Expand
Choroid Sprouting Assay: An Ex Vivo Model of Microvascular Angiogenesis
TLDR
This reproducible ex vivo angiogenesis assay can be used to evaluate angiogenic potential of pharmacologic compounds on microvessels and can take advantage of genetically manipulated mouse tissue for microvascular disease research. Expand
Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants.
TLDR
Administration of three doses of ibuprofen within 3 hours after birth in preterm neonates reduced the incidence of PDA without causing notable early adverse drug reactions in this phase I trial. Expand
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