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Cyclosporine A (CsA), a widely used immunosuppressant shows cytotoxic effects by either inducing apoptosis or redirecting the… Expand Peptidyl-prolyl cis/trans isomerases (PPIs) catalyze cis/trans isomerization of peptide bonds preceding proline residues. The… Expand Cyclophilin B (CypB) is a 21-kDa protein with peptidyl-prolyl cis-trans isomerase activity that functions as a transcriptional… Expand Cyclophilins are cellular peptidyl isomerases that have been implicated in regulating hepatitis C virus (HCV) replication… Expand Prolonged accumulation of misfolded proteins in the endoplasmic reticulum (ER) results in ER stress-mediated apoptosis… Expand Initially identified as a cyclosporin-A binding protein, cyclophilin B (CyPB) is an inflammatory mediator that induces adhesion… Expand Many of the biological functions of heparan sulfate (HS) proteoglycans can be attributed to specialized structures within HS… Expand OBJECTIVE
To study cyclophilin B, a protein newly identified as a secretion product of cultured chondrocytes, in the context of… Expand Cyclophilin B (CypB) possesses two antigenic epitopes (CypB84–92 and CypB91–99) recognized by HLA-A24-restricted and tumor… Expand Cyclophilin B is targeted to the secretory pathway via an endoplasmic reticulum signal sequence. We analyzed the localization and… Expand