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cycloguanil

Known as: Chlorguanide Triazine, cycloquanil, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,2,5-triazine-2,4-diamine 
 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite… Expand
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Highly Cited
2003
Highly Cited
2003
ObjectiveTo determine the effects of late pregnancy and also oestrogen supplementation on the CYP2C19-mediated biotransformation… Expand
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Review
2002
Review
2002
Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large differences in the pharmacokinetics of a number of… Expand
Highly Cited
1998
Highly Cited
1998
The lack of suitable antimalarial agents to replace chloroquine and pyrimethamine/sulfadoxine threatens efforts to control the… Expand
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Highly Cited
1997
Highly Cited
1997
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors… Expand
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Highly Cited
1997
Highly Cited
1997
Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have… Expand
Highly Cited
1990
Highly Cited
1990
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and… Expand
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Highly Cited
1990
Highly Cited
1990
Cycloguanil, the active metabolite of the antimalarial drug proguanil, is an inhibitor of dihydrofolate reductase as is another… Expand
Highly Cited
1980
Highly Cited
1980
A series of N-benzyloxydihydrotriazines were prepared and found to have antimalarial activity against Plasmodium berghei… Expand
Highly Cited
1968
Highly Cited
1968
Summary Maturation of trophozoites of Plasmodium falciparum into schizonts was observed during studies in which defibrinated… Expand