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cycloguanil

Known as: Chlorguanide Triazine, cycloquanil, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,2,5-triazine-2,4-diamine 
 
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite… Expand
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2003
2003
OBJECTIVES To assess the relationship between the presence of DHFR and DHPS mutations in Plasmodium falciparum, parasite in vitro… Expand
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Highly Cited
2003
Highly Cited
2003
ObjectiveTo determine the effects of late pregnancy and also oestrogen supplementation on the CYP2C19-mediated biotransformation… Expand
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Review
2002
Review
2002
Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large differences in the pharmacokinetics of a number of… Expand
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Highly Cited
1998
Highly Cited
1998
The lack of suitable antimalarial agents to replace chloroquine and pyrimethamine/sulfadoxine threatens efforts to control the… Expand
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Highly Cited
1997
Highly Cited
1997
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors… Expand
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Highly Cited
1997
Highly Cited
1997
Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have… Expand
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Highly Cited
1996
Highly Cited
1996
Plasmodium falciparum isolates from 24 Papua New Guinean patients with symptomatic malaria were tested for susceptibility to… Expand
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Highly Cited
1990
Highly Cited
1990
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and… Expand
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Highly Cited
1990
Highly Cited
1990
Cycloguanil, the active metabolite of the antimalarial drug proguanil, is an inhibitor of dihydrofolate reductase as is another… Expand
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