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cycloguanil
Known as:
Chlorguanide Triazine
, cycloquanil
, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,2,5-triazine-2,4-diamine
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National Institutes of Health
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Related topics
Related topics
6 relations
Broader (4)
Antimalarials
Folic Acid Antagonists
Proguanil
Triazines
Cycloguanil:MCnc:Pt:Ser/Plas:Qn
Narrower (1)
cycloguanil hydrochloride
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
H. R. Bridges
,
Andrew J. Y. Jones
,
M. Pollak
,
J. Hirst
The Biochemical journal
2014
Corpus ID: 10019625
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite…
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Review
2002
Review
2002
Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism
Z. Desta
,
Xiaojiong Zhao
,
Jae-Gook Shin
,
D. Flockhart
Clinical pharmacokinetics
2002
Corpus ID: 27616494
Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large differences in the pharmacokinetics of a number of…
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Highly Cited
1998
Highly Cited
1998
Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase.
D. Fidock
,
T. Nomura
,
T. Wellems
Molecular pharmacology
1998
Corpus ID: 10115046
The lack of suitable antimalarial agents to replace chloroquine and pyrimethamine/sulfadoxine threatens efforts to control the…
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Highly Cited
1997
Highly Cited
1997
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.
D. Fidock
,
T. Wellems
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 7600679
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors…
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Highly Cited
1997
Highly Cited
1997
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
W. Sirawaraporn
,
T. Sathitkul
,
R. Sirawaraporn
,
Y. Yuthavong
,
D. Santi
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 25440681
Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have…
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Review
1997
Review
1997
32 bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes
J. Rappaport
,
Y. Cho
,
H. Hendel
,
E. J. Schwartz
,
F. Schachter
,
J. Zagury
The Lancet
1997
Corpus ID: 12801415
Highly Cited
1990
Highly Cited
1990
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.
D. Peterson
,
W. Milhous
,
T. Wellems
Proceedings of the National Academy of Sciences…
1990
Corpus ID: 2191273
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and…
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Highly Cited
1990
Highly Cited
1990
Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.
S. Foote
,
D. Galatis
,
A. Cowman
Proceedings of the National Academy of Sciences…
1990
Corpus ID: 30474893
Cycloguanil, the active metabolite of the antimalarial drug proguanil, is an inhibitor of dihydrofolate reductase as is another…
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Highly Cited
1987
Highly Cited
1987
The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice.
A. Chawira
,
D. Warhurst
,
B. Robinson
,
W. Peters
Transactions of the Royal Society of Tropical…
1987
Corpus ID: 36896649
Highly Cited
1980
Highly Cited
1980
The antimalarial activity of N-benzyloxydihydrotriazines. I. The activity of clociguanil (BRL 50216) against rodent malaria, and studies on its mode of action.
D. J. Knight
,
W. Peters
Annals of tropical medicine and parasitology
1980
Corpus ID: 33661850
A series of N-benzyloxydihydrotriazines were prepared and found to have antimalarial activity against Plasmodium berghei…
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