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cycloguanil

Known as: Chlorguanide Triazine, cycloquanil, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,2,5-triazine-2,4-diamine 
 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

AntimalarialsFolic Acid AntagonistsProguanilTriazines
Cycloguanil:MCnc:Pt:Ser/Plas:Qn

Narrower (1)

cycloguanil hydrochloride

Papers overview

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Highly Cited
2014
Highly Cited
2014
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite… Expand
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2003
2003
DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine treatment efficacy.
OBJECTIVES To assess the relationship between the presence of DHFR and DHPS mutations in Plasmodium falciparum, parasite in vitro… Expand
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Highly Cited
2003
Highly Cited
2003
Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil
ObjectiveTo determine the effects of late pregnancy and also oestrogen supplementation on the CYP2C19-mediated biotransformation… Expand
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Review
2002
Review
2002
Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism
Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large differences in the pharmacokinetics of a number of… Expand
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Highly Cited
1998
Highly Cited
1998
Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase.
The lack of suitable antimalarial agents to replace chloroquine and pyrimethamine/sulfadoxine threatens efforts to control the… Expand
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Highly Cited
1997
Highly Cited
1997
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors… Expand
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Highly Cited
1997
Highly Cited
1997
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase.
Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have… Expand
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Highly Cited
1996
Highly Cited
1996
Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New…
Plasmodium falciparum isolates from 24 Papua New Guinean patients with symptomatic malaria were tested for susceptibility to… Expand
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Highly Cited
1990
Highly Cited
1990
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and… Expand
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Highly Cited
1990
Highly Cited
1990
Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.
Cycloguanil, the active metabolite of the antimalarial drug proguanil, is an inhibitor of dihydrofolate reductase as is another… Expand
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