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cycloguanil

Known as: Chlorguanide Triazine, cycloquanil, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,2,5-triazine-2,4-diamine 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite… 
Review
2002
Review
2002
Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large differences in the pharmacokinetics of a number of… 
Highly Cited
1998
Highly Cited
1998
The lack of suitable antimalarial agents to replace chloroquine and pyrimethamine/sulfadoxine threatens efforts to control the… 
Highly Cited
1997
Highly Cited
1997
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors… 
Highly Cited
1997
Highly Cited
1997
Single and multiple mutations at residues 16, 51, 59, 108, and 164 of Plasmodium falciparum dihydrofolate reductase (pfDHFR) have… 
Highly Cited
1990
Highly Cited
1990
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and… 
Highly Cited
1990
Highly Cited
1990
Cycloguanil, the active metabolite of the antimalarial drug proguanil, is an inhibitor of dihydrofolate reductase as is another… 
Highly Cited
1980
Highly Cited
1980
A series of N-benzyloxydihydrotriazines were prepared and found to have antimalarial activity against Plasmodium berghei…