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cycloguanil

Known as: Chlorguanide Triazine, cycloquanil, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,2,5-triazine-2,4-diamine 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

AntimalarialsFolic Acid AntagonistsProguanilTriazines
Cycloguanil:MCnc:Pt:Ser/Plas:Qn

Narrower (1)

cycloguanil hydrochloride

Papers overview

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2015
2015
Bioactive glycosides from the African medicinal plant Boerhavia erecta L.
Phytochemical studies of the previously unexplored stem of Boerhavia erecta from Burkina Faso, resulted in the isolation of an… 
2009
2009
Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases
AbstractComparative molecular field analysis (CoMFA) and quantum chemical calculations were performed on cycloguanil (Cyc… 
2000
2000
In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes.
AIM To identify the cytochrome P450 isoforms involved in proguanil (PG) activation to cycloguanil (CG) in Chinese liver… 
1999
1999
Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.
AIMS To compare the oxidative metabolism of (S)-mephenytoin and proguanil in vitro and to determine the involvement of various… 
1999
1999
In Vitro Culture and Drug Sensitivity Assay ofPlasmodium falciparum with Nonserum Substitute and Acute-Phase Sera
ABSTRACT The short-term in vitro growth of Plasmodium falciparumparasites in the asexual erythrocytic stage and the in vitro… 
1997
1997
Effects of folic and folinic acids in the activities of cycloguanil and WR99210 against Plasmodium falciparum in erythrocytic culture.
The in-vitro effects of folinic acid on the antimalarial activities of the triazine antifolates, cycloguanil and WR99210, were… 
1997
1997
Sensibilité in vitro de Plasmodium falciparum aux antifoliniques (triméthoprime, pyriméthamine, cycloguanil): étude sur 29 souches africaines.
La sensibilite in vitro a trois inhibiteurs de la dihydrofolate reductase (pyrimethamine, cycloguanil, trimethoprime) a ete… 
1997
1997
In vitro sensitivity of Plasmodium falciparum to anti-folinic agents (trimethoprim, pyrimethamine, cycloguanil): a study of 29 African strains.
The in vitro drug sensitivity of three dihydrofolate reductase inhibitors (pyrimethamine, cycloguanil, trimethoprim) was… 
1996
1996
Plasmodium falciparum: mutation pattern in the dihydrofolate reductase-thymidylate synthase genes of Vietnamese isolates, a novel mutation, and coexistence of two clones in a Thai patient.
Pyrimethamine and cycloguanil resistance of Plasmodium falciparum has been linked to mutations in the dihydrofolate reductase… 
1974
1974
Assessment of causal prophylactic activity in Plasmodium berghei yoelii and its value for the development of new antimalarial drugs.
The causal prophylactic activity of several reference and experimental antimalarial compounds was assessed in sporozoite-induced… 
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