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cycloguanil

Known as: Chlorguanide Triazine, cycloquanil, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,2,5-triazine-2,4-diamine 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

AntimalarialsFolic Acid AntagonistsProguanilTriazines
Cycloguanil:MCnc:Pt:Ser/Plas:Qn

Narrower (1)

cycloguanil hydrochloride

Papers overview

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2018
2018
OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil
Cycloguanil, the active metabolite of proguanil, acts on malaria schizonts in erythrocytes and hepatocytes. We analyzed the… 
Highly Cited
2005
Highly Cited
2005
Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents.
2004
2004
Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors.
Highly Cited
2003
Highly Cited
2003
Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil
ObjectiveTo determine the effects of late pregnancy and also oestrogen supplementation on the CYP2C19-mediated biotransformation… 
Review
1997
Review
1997
32 bp CCR-5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes
Highly Cited
1996
Highly Cited
1996
Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New…
Plasmodium falciparum isolates from 24 Papua New Guinean patients with symptomatic malaria were tested for susceptibility to… 
Highly Cited
1987
Highly Cited
1987
The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice.
Highly Cited
1986
Highly Cited
1986
Qinghaosu resistance in rodent malaria.
Highly Cited
1984
Highly Cited
1984
The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro.
Using an in vitro radioisotopic method, the activity was measured of proguanil, its metabolites cycloguanil and p… 
Highly Cited
1968
Highly Cited
1968
Effects of chloroquine, quinine, and cycloguanil upon the maturation of asexual erythrocytic forms of two strains of Plasmodium falciparum in vitro.
Summary Maturation of trophozoites of Plasmodium falciparum into schizonts was observed during studies in which defibrinated… 
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