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copolymer I (synthetic peptide)

Known as: Cop 1, copolymer I, synthetic peptide copolymer I 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

(T,G)-A-Lsynthetic peptide
Multiple Sclerosisglatiramer acetate

Papers overview

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2003
2003
Characterization of a Novel Non-Constitutive Photomorphogenic cop1 Allele1
A specific light program consisting of multiple treatments with alternating red and far-red light pulses was used to isolate… Expand
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Highly Cited
1999
Highly Cited
1999
Immunomodulation of experimental autoimmune encephalomyelitis by oral administration of copolymer 1.
The activity of copolymer 1 (Cop 1, Copaxone, glatiramer acetate) in suppressing experimental autoimmune encephalomyelitis (EAE… Expand
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Review
1997
Review
1997
Cop 1 as a candidate drug for multiple sclerosis.
Copolymer 1 (Cop 1), a synthetic copolymer of amino acids, is very effective in suppression of experimental autoimmune… Expand
1996
1996
Combinations of drugs
  • L. Kappos
  • Multiple sclerosis
  • 1996
    • Corpus ID: 9917094
As a result of recent therapeutic trials, recombinant Interferon beta (r/FNβ)-1b and-1a as well as Copolymer 1 (COP 1) and to… Expand
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1990
1990
Cell-mediated immune response to copolymer I in multiple sclerosis measured by the macrophage procoagulant activity assay.
The macrophage/monocyte procoagulant activity (MPCA) assay, a sensitive and specific in vitro test for cell-mediated immunity… Expand
Highly Cited
1988
Highly Cited
1988
Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.
Cop 1 is a synthetic basic random copolymer of L-alanine, L-glutamic acid, L-lysine, and L-tyrosine in a residue molar ratio of 6… Expand
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Highly Cited
1987
Highly Cited
1987
A pilot trial of Cop 1 in exacerbating-remitting multiple sclerosis.
Cop 1 is a random polymer (molecular weight, 14,000 to 23,000) simulating myelin basic protein. It is synthesized by polymerizing… Expand
1986
1986
Human cellular immune response to copolymer I and myelin basic protein
Copolymer I (Cop I) is being tested as a treatment for MS because it protects animals against experimental allergic… Expand
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1985
1985
Immunogenic potentials of copolymer I in normal human lymphocytes
Copolymer I (COP I), a nonencephalitogenic polypeptide analogous to myelin basic protein, is currently being tested for possible… Expand
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Highly Cited
1982
Highly Cited
1982
Multiple sclerosis: Trial of a synthetic polypeptide
A synthetic polypeptide, copolymer I (COP I), composed of alanine, glutamic acid, lysine, and tyrosine, has been demonstrated to… Expand
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