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The kinetics of formation of native ribonuclease during oxidation of the reduced polypeptide chain.
TLDR
There existed a considerable lag phase before enzymatic activity appeared after the sample of bovine pancreatic ribonuclease was treated with mercaptoethanol in urea, during which period the sulfhydrl titer and the specific optical rotation changed along a curve similar to that of a first-order reaction. Expand
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.
TLDR
It is conceivable that combinatorial receptor interactions diversify signal transduction and confer double regulation, in cis and in trans, of the superior mitogenic activity of the kinase‐defective ErbB‐3. Expand
Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide
TLDR
Three random basic copolymers of amino acids were tested for their effect on experimental allergic encephalomyelitis and one of them, denoted as Cop 1, showed a marked suppressive effect on the disease. Expand
Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors.
TLDR
The realization that ErbB-2 is a master regulator of a signaling network that drives epithelial cell proliferation identifies this protein as a target for cancer therapy, and various Erb B-2-directed therapeutic approaches, including immunological and genetic therapies, demonstrate promising clinical potential. Expand
The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice.
TLDR
The results indicate that the immunomodulator GA exerts not only an antiinflammatory effect, but also enhances neuroprotection and regeneration of neural elements in the diseased brain. Expand
The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors.
TLDR
Oncogenicity of ErbB-2 in human epithelia may not rely on the existence of a specific ligand but rather on its ability to act as a coreceptor for multiple stroma-derived growth factors. Expand
T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies.
TLDR
It is shown here that active immunization withCop-1 administered in adjuvant, as well as adoptive transfer of T cells reactive to Cop-1, can inhibit the progression of secondary degeneration after crush injury of the rat optic nerve. Expand
Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1.
TLDR
Cop 1-induced Th2 cells cross the blood-brain barrier and accumulate in the CNS, where they can be stimulated in situ by MBP and thereby exert therapeutic effects in the diseased organ. Expand
Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.
TLDR
It is shown that enhanced degradation is preceded by poly-ubiquitination of ErbB-2, and the therapeutic potential of certain antibodies may be due to their ability to direct Erb B-2 to a c-Cbl-regulated proteolytic pathway. Expand
Roles for growth factors in cancer progression.
TLDR
Cancer-associated activating mutations that impinge on these pathways often relieve, in part, the reliance of tumors on growth factors, which extends the roles for polypeptide factors to very late phases of tumor progression and offers opportunities for cancer therapy. Expand
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