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constitutive androstane receptor

Known as: Constitutive Active Receptor, CAR orphan nuclear receptor, CAR nuclear receptor 
Nuclear receptor subfamily 1 group I member 3 (352 aa, ~40 kDa) is encoded by the human NR1I3 gene. This protein is involved in the regulation of… Expand
National Institutes of Health

Papers overview

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Review
2011
Review
2011
The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays a central role in a regulatory network… Expand
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Highly Cited
2008
Highly Cited
2008
The transcriptional regulator CONSTANS (CO) promotes flowering of Arabidopsis under long summer days (LDs) but not under short… Expand
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Highly Cited
2007
Highly Cited
2007
Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR) are capable of regulating CYP3A4 and CYP2B6… Expand
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Highly Cited
2007
Highly Cited
2007
In our study, we tested the hypothesis whether valproic acid (VPA) in therapeutic concentrations has potential to affect… Expand
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Highly Cited
2006
Highly Cited
2006
Accumulated evidence suggests that cross-talk between the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR… Expand
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Highly Cited
2005
Highly Cited
2005
The constitutive androstane receptor (CAR, NR1I3) is a central regulator of xenobiotic metabolism. CAR activation induces hepatic… Expand
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Highly Cited
2004
Highly Cited
2004
Light, in a quality- and quantity-dependent fashion, induces nuclear import of the plant photoreceptors phytochrome, promotes… Expand
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Highly Cited
2003
Highly Cited
2003
Bilirubin clearance is one of the numerous important functions of the liver. Defects in this process result in jaundice, which is… Expand
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Highly Cited
2002
Highly Cited
2002
The nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play central roles in protecting the body… Expand
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Highly Cited
2000
Highly Cited
2000
Most developing thymocytes undergo apoptosis because they cannot interact productively with molecules encoded by the major… Expand
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