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constitutive androstane receptor

Known as: Constitutive Active Receptor, CAR orphan nuclear receptor, CAR nuclear receptor 
Nuclear receptor subfamily 1 group I member 3 (352 aa, ~40 kDa) is encoded by the human NR1I3 gene. This protein is involved in the regulation of… Expand
National Institutes of Health

Related topics

Related topics

25 relations
Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation
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Narrower (2)

NR1I3 protein, humanconstitutive androstane receptor beta

Broader (1)

Receptors, Cytoplasmic and Nuclear

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
The PGC-1 family of regulated coactivators, consisting of PGC-1α, PGC-1β and PRC, plays a central role in a regulatory network… Expand
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Highly Cited
2008
Highly Cited
2008
Arabidopsis COP1 shapes the temporal pattern of CO accumulation conferring a photoperiodic flowering response
The transcriptional regulator CONSTANS (CO) promotes flowering of Arabidopsis under long summer days (LDs) but not under short… Expand
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Highly Cited
2007
Highly Cited
2007
Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers
Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR) are capable of regulating CYP3A4 and CYP2B6… Expand
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Highly Cited
2007
Highly Cited
2007
Valproic Acid Induces CYP3A4 and MDR1 Gene Expression by Activation of Constitutive Androstane Receptor and Pregnane X Receptor Pathways
In our study, we tested the hypothesis whether valproic acid (VPA) in therapeutic concentrations has potential to affect… Expand
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Highly Cited
2006
Highly Cited
2006
Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor
Accumulated evidence suggests that cross-talk between the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR… Expand
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Highly Cited
2005
Highly Cited
2005
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
The constitutive androstane receptor (CAR, NR1I3) is a central regulator of xenobiotic metabolism. CAR activation induces hepatic… Expand
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Highly Cited
2004
Highly Cited
2004
Constitutive Photomorphogenesis 1 and Multiple Photoreceptors Control Degradation of Phytochrome Interacting Factor 3, a Transcription Factor Required for Light Signaling in Arabidopsis
Light, in a quality- and quantity-dependent fashion, induces nuclear import of the plant photoreceptors phytochrome, promotes… Expand
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Highly Cited
2003
Highly Cited
2003
Induction of bilirubin clearance by the constitutive androstane receptor (CAR)
Bilirubin clearance is one of the numerous important functions of the liver. Defects in this process result in jaundice, which is… Expand
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Highly Cited
2002
Highly Cited
2002
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
The nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play central roles in protecting the body… Expand
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Highly Cited
2000
Highly Cited
2000
Requirement for RORgamma in thymocyte survival and lymphoid organ development.
Most developing thymocytes undergo apoptosis because they cannot interact productively with molecules encoded by the major… Expand
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