FAQ

constitutive androstane receptor

Known as: Constitutive Active Receptor, CAR orphan nuclear receptor, CAR nuclear receptor 
Nuclear receptor subfamily 1 group I member 3 (352 aa, ~40 kDa) is encoded by the human NR1I3 gene. This protein is involved in the regulation of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
0204019982018

Related topics

Related topics

21 relations
Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
constitutive androstane receptor
Cell Nucleus
Cytoplasm
Homeostasis
Cell Differentiation process
Cell Proliferation

Papers overview

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Highly Cited
2007
Highly Cited
2007
Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.
Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR) are capable of regulating CYP3A4 and CYP2B6… (More)
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Highly Cited
2005
Highly Cited
2005
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
The constitutive androstane receptor (CAR, NR1I3) is a central regulator of xenobiotic metabolism. CAR activation induces hepatic… (More)
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Highly Cited
2005
Highly Cited
2005
Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.
Cholestasis is associated with accumulation of bile acids and lipids, and liver injury. The constitutive androstane receptor (CAR… (More)
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Highly Cited
2003
Highly Cited
2003
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.
The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are important in maintaining bile acid… (More)
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Highly Cited
2003
Highly Cited
2003
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight… (More)
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Highly Cited
2002
Highly Cited
2002
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
The nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play central roles in protecting the body… (More)
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Highly Cited
2002
Highly Cited
2002
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… (More)
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Highly Cited
2002
Highly Cited
2002
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.
The NR1I subfamily of nuclear receptors contains a phylogenetically diverse array of receptors related to the mammalian pregnane… (More)
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Highly Cited
2002
Highly Cited
2002
Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.
Although cytochrome P450 2C9 (CYP2C9) is a major CYP expressed in the adult human liver, its mechanism of regulation is poorly… (More)
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Highly Cited
2000
Highly Cited
2000
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR… (More)
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