constitutive androstane receptor

Known as: Constitutive Active Receptor, CAR orphan nuclear receptor, CAR nuclear receptor 
Nuclear receptor subfamily 1 group I member 3 (352 aa, ~40 kDa) is encoded by the human NR1I3 gene. This protein is involved in the regulation of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
0204019982018

Papers overview

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Highly Cited
2007
Highly Cited
2007
Both the human pregnane X receptor (hPXR) and constitutive androstane receptor (hCAR) are capable of regulating CYP3A4 and CYP2B6… (More)
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Highly Cited
2005
Highly Cited
2005
The constitutive androstane receptor (CAR, NR1I3) is a central regulator of xenobiotic metabolism. CAR activation induces hepatic… (More)
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Highly Cited
2005
Highly Cited
2005
Cholestasis is associated with accumulation of bile acids and lipids, and liver injury. The constitutive androstane receptor (CAR… (More)
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Highly Cited
2003
Highly Cited
2003
The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are important in maintaining bile acid… (More)
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Highly Cited
2003
Highly Cited
2003
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight… (More)
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Highly Cited
2002
Highly Cited
2002
The nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play central roles in protecting the body… (More)
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Highly Cited
2002
Highly Cited
2002
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… (More)
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Highly Cited
2002
Highly Cited
2002
The NR1I subfamily of nuclear receptors contains a phylogenetically diverse array of receptors related to the mammalian pregnane… (More)
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Highly Cited
2002
Highly Cited
2002
Although cytochrome P450 2C9 (CYP2C9) is a major CYP expressed in the adult human liver, its mechanism of regulation is poorly… (More)
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Highly Cited
2000
Highly Cited
2000
Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR… (More)
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