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constitutive androstane receptor

Known as: Constitutive Active Receptor, CAR orphan nuclear receptor, CAR nuclear receptor 
Nuclear receptor subfamily 1 group I member 3 (352 aa, ~40 kDa) is encoded by the human NR1I3 gene. This protein is involved in the regulation of… 
National Institutes of Health

Related topics

Related topics

25 relations
Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation

Narrower (2)

NR1I3 protein, humanconstitutive androstane receptor beta

Broader (1)

Receptors, Cytoplasmic and Nuclear

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor
Constitutive androstane receptor (CAR) is a nuclear receptor that regulates the transcription of target genes, including CYP2B… 
2012
2012
Identification of Novel Activators of Constitutive Androstane Receptor from FDA-Approved Drugs by Integrated Computational and Biological Approaches
The constitutive androstane receptor (CAR, NR1I3) is a xenobiotic sensor governing the transcription of numerous hepatic genes… 
2011
2011
Constitutive Androstane Receptor Activation Decreases Plasma Apolipoprotein B–Containing Lipoproteins and Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice
Objective—The goal of this study was to determine the impact of the nuclear receptor constitutive androstane receptor (CAR) on… 
2008
2008
Nuclear Receptor Coactivator 6 Mediates the Synergistic Activation of Human Cytochrome P-450 2C9 by the Constitutive Androstane Receptor and Hepatic Nuclear Factor-4α
Nuclear receptor coactivator 6 (NCOA6) also known as PRIP/RAP250/ASC-2 anchors a steady-state complex of cofactors and function… 
2008
2008
COP1D, an alternatively spliced constitutive photomorphogenic-1 (COP1) product, stabilizes UV stress-induced c-Jun through inhibition of full-length COP1
COP1 is an evolutionarily conserved RING-finger ubiquitin ligase acting within a Cullin-RING ligase (CRL) complex that promotes… 
2005
2005
Structural Determinants of Constitutive Androstane Receptor Required for Its Glucocorticoid Receptor Interacting Protein-1-mediated Nuclear Accumulation*
Nuclear translocation of constitutive androstane receptor (CAR) is a primary mechanism for the induction of cytochrome P450 genes… 
Highly Cited
2003
Highly Cited
2003
Characterization of DNA Complexes Formed by the Nuclear Receptor Constitutive Androstane Receptor*
The nuclear receptor constitutive androstane receptor (CAR) acts as a xenobiotic sensor and regulates the expression of enzymes… 
2000
2000
p62 functions as a p38 MAP kinase regulator.
By screening a HeLa cDNA library to isolate genes encoding p38-regulating proteins, we have isolated two independent clones which… 
1999
1999
A Novel Motif Mediates the Targeting of theArabidopsis COP1 Protein to Subnuclear Foci*
The constitutive photomorphogenesis 1 (COP1) protein of Arabidopsis thaliana accumulates in discrete subnuclear foci. To better… 
1995
1995
Transcriptional Regulation of the Cholesteryl Ester Transfer Protein Gene by the Orphan Nuclear Hormone Receptor Apolipoprotein AI Regulatory Protein-1 (*)
We have defined a 105-base pair tissue-restricted promoter for the cholesteryl ester transfer protein (CETP) gene that contains a… 
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