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The Origin and Evolution of Mutations in Acute Myeloid Leukemia
TLDR
The data suggest that most of the mutations found in AML genomes are actually random events that occurred in HSPCs before they acquired the initiating mutation; the mutational history of that cell is "captured" as the clone expands. Expand
Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1
TLDR
PICK1 (protein interacting with C kinase), a PDZ domain-containing protein, interacts with the C termini of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptors in vitro and in vivo and suggests that PICK1 may play an important role in the modulation of synaptic transmission by regulating the synaptic targeting of AMPA receptors. Expand
Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors
TLDR
It is found that the N-ethylmaleimide-sensitive factor (NSF), a protein involved in membrane fusion events, specifically interacts with the C terminus of the GluR2 and GLUR4c subunits of AMPA receptors in vitro and in vivo. Expand
Cerebellar Long-Term Depression Requires PKC-Regulated Interactions between GluR2/3 and PDZ Domain–Containing Proteins
TLDR
Findings indicate that expression of cerebellar LTD requires PKC-regulated interactions between the carboxy-terminal of GluR2/3 and PDZ domain-containing proteins. Expand
Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT
TLDR
A deep learning model can accurately detect COVID-19 and differentiate it from community acquired pneumonia and other lung diseases. Expand
Targeted In Vivo Mutations of the AMPA Receptor Subunit GluR2 and Its Interacting Protein PICK1 Eliminate Cerebellar Long-Term Depression
TLDR
It is shown that targeted mutation of PICK1, the GluR2 C-terminal PDZ ligand, or the GLUR2 PKC phosphorylation site eliminates cerebellar LTD in mice and demonstrates that P Pick1-GluR1 PDZ-based interactions and Glu R2 phosphorylated are required for LTD expression in the cerebellum. Expand
Lipid Binding Regulates Synaptic Targeting of PICK1, AMPA Receptor Trafficking, and Synaptic Plasticity
TLDR
It is shown that PICK1 directly binds to lipids, mainly phosphoinositides, via its BAR (Bin/amphiphysin/Rvs) domain, which is important for its synaptic targeting, AMPA receptor trafficking, and synaptic plasticity. Expand
Calcium-Permeable AMPA Receptor Plasticity Is Mediated by Subunit-Specific Interactions with PICK1 and NSF
TLDR
It is found that two GluR2-interacting proteins, the PDZ domain-containing Protein interacting with C kinase (PICK1) and N-ethylmaleimide sensitive fusion protein (NSF), are specifically required for CARP. Expand
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
TLDR
It is found that thrombospondin 1 increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons, while knocking down endogenous NL1 inhibited TSP1's effect. Expand
APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity
TLDR
A mechanism by which EphA4 regulates homeostatic plasticity through an APCCdh1-dependent degradation pathway is defined, which requires the ubiquitin proteasome system (UPS). Expand
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