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The Origin and Evolution of Mutations in Acute Myeloid Leukemia
Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT
A deep learning model can accurately detect COVID-19 and differentiate it from community acquired pneumonia and other lung diseases.
Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1
Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors
Cerebellar Long-Term Depression Requires PKC-Regulated Interactions between GluR2/3 and PDZ Domain–Containing Proteins
Targeted In Vivo Mutations of the AMPA Receptor Subunit GluR2 and Its Interacting Protein PICK1 Eliminate Cerebellar Long-Term Depression
Lipid Binding Regulates Synaptic Targeting of PICK1, AMPA Receptor Trafficking, and Synaptic Plasticity
It is shown that PICK1 directly binds to lipids, mainly phosphoinositides, via its BAR (Bin/amphiphysin/Rvs) domain, which is important for its synaptic targeting, AMPA receptor trafficking, and synaptic plasticity.
Calcium-Permeable AMPA Receptor Plasticity Is Mediated by Subunit-Specific Interactions with PICK1 and NSF
APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity
A mechanism by which EphA4 regulates homeostatic plasticity through an APCCdh1-dependent degradation pathway is defined, which requires the ubiquitin proteasome system (UPS).
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
It is found that thrombospondin 1 increased the speed of synapse formation in young neurons, but not the final density of synapses in mature neurons, while knocking down endogenous NL1 inhibited TSP1's effect.