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complestatin

Known as: chloropeptin II 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

ChlorophenolsCyclic Peptides

Narrower (1)

isocomplestatin

Papers overview

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Highly Cited
2010
Highly Cited
2010
Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization.
Full details of the initial development and continued examination of a powerful intramolecular palladium(0)-mediated indole… 
2010
2010
Total synthesis of complestatin (chloropeptin II).
Complestatin was isolated in 1980 from the mycelium of Streptomyces lavendulae as inhibitor of alternative pathways to the… 
Highly Cited
2009
Highly Cited
2009
Total synthesis of chloropeptin II (complestatin) and chloropeptin I.
The first total synthesis of chloropeptin II (1, complestatin) is disclosed. Key elements of the approach include the use of an… 
Highly Cited
2008
Highly Cited
2008
Synthesis of diastereomers of complestatin and chloropeptin I: substrate-dependent atropstereoselectivity of the intramolecular Suzuki-Miyaura reaction.
Atropisomers as well as CC2 epimers of complestatin and chloropeptin I are readily synthesized through an intramol. SNAr reaction… 
2007
2007
Synthesis of DEFG ring of complestatin and chloropeptin I: highly atropdiastereoselective macrocyclization by intramolecular Suzuki-Miyaura reaction.
Palladium-catalyzed intramolecular Suzuki-Miyaura reaction of linear tripeptide (23) afforded the 16-membered DEFG ring of… 
Highly Cited
2001
Highly Cited
2001
Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster
Streptomyces lavendulae produces complestatin, a cyclic peptide natural product that antagonizes pharmacologically relevant… 
Highly Cited
2001
Highly Cited
2001
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid…
From the screening of a microbial extract library, isocomplestatin (1), a new axial-chiral isomer of complestatin (2) which is a… 
Highly Cited
1999
Highly Cited
1999
Two syntheses of the 16- and 17-membered DEF ring systems of chloropeptin and complestatin.
[formula: see text] Two syntheses of a model system of the DEF ring system of complestatin and chloropeptin are described. The… 
1997
1997
Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I.
The structure of chloropeptin I, a gp120-CD4 binding inhibitor having a potent anti-HIV activity, was elucidated by 1H and 13C… 
Highly Cited
1989
Highly Cited
1989
Complestatin, a potent anti-complement substance produced by Streptomyces lavendulae. I. Fermentation, isolation and biological characterization.
A new potent inhibitor of complement system, named complestatin, was isolated from the mycelium of Streptomyces lavendulae SANK… 
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