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complestatin

Known as: chloropeptin II 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

ChlorophenolsCyclic Peptides

Narrower (1)

isocomplestatin

Papers overview

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2016
2016
Generation of New Complestatin Analogues by Heterologous Expression of the Complestatin Biosynthetic Gene Cluster from Streptomyces chartreusis AN1542.
The heterologous expression of the biosynthetic gene cluster (BGC) of natural products enables the production of complex… Expand
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2010
2010
Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization.
Full details of the initial development and continued examination of a powerful intramolecular palladium(0)-mediated indole… Expand
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2009
2009
Total synthesis of chloropeptin II (complestatin) and chloropeptin I.
The first total synthesis of chloropeptin II (1, complestatin) is disclosed. Key elements of the approach include the use of an… Expand
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2008
2008
Synthesis of diastereomers of complestatin and chloropeptin I: substrate-dependent atropstereoselectivity of the intramolecular Suzuki-Miyaura reaction.
Atropisomers as well as CC2 epimers of complestatin and chloropeptin I are readily synthesized through an intramol. SNAr reaction… Expand
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2004
2004
Complestatin prevents apoptotic cell death: inhibition of a mitochondrial caspase pathway through AKT/PKB activation.
Complestatin, a bicyclo hexapeptide from Streptomyces, was isolated as a possible regulator of neuronal cell death. In this study… Expand
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2001
2001
Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster
Streptomyces lavendulae produces complestatin, a cyclic peptide natural product that antagonizes pharmacologically relevant… Expand
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2001
2001
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid…
From the screening of a microbial extract library, isocomplestatin (1), a new axial-chiral isomer of complestatin (2) which is a… Expand
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1997
1997
Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I.
The structure of chloropeptin I, a gp120-CD4 binding inhibitor having a potent anti-HIV activity, was elucidated by 1H and 13C… Expand
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1991
1991
Inhibition of human immunodeficiency virus type-1-induced syncytium formation and cytopathicity by complestatin.
Complestatin, an anti-complement agent, was shown to be a potent inhibitor of human immunodeficiency virus type 1 (HIV-1… Expand
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1989
1989
Complestatin, a potent anti-complement substance produced by Streptomyces lavendulae. I. Fermentation, isolation and biological characterization.
A new potent inhibitor of complement system, named complestatin, was isolated from the mycelium of Streptomyces lavendulae SANK… Expand
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