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complement factor H, human

Known as: Human Factor H, H Factor 1, Factor H 
Complement factor H (1231 aa, ~139 kDa) is encoded by the human CFH gene. This protein is involved in the activation of the complement pathway.
National Institutes of Health

Related topics

Related topics

9 relations
CFH geneCFHR2 geneComplement ActivationComplement Pathway, Alternative

Broader (2)

COMPLEMENT FACTOR HComplement 3b Inactivators

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The Murine Factor H-Related Protein FHR-B Promotes Complement Activation
Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of… 
2017
2017
Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation
Platelet/granulocyte aggregates (PGAs) increase thromboinflammation in the vasculature, and PGA formation is tightly controlled… 
2016
2016
Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.
Streptococcus pneumoniae is a major cause of life-threatening infections. Complement activation plays a vital role in… 
2014
2014
Two cross‐reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties
Factor H binding protein (fHbp) is one of the main antigens of the 4‐component meningococcus B (4CMenB) multicomponent vaccine… 
2014
2014
Anti-factor H autoantibodies assay.
Non-Shiga-toxin-associated hemolytic uremic syndrome (atypical HUS) is a rare form of thrombotic microangiopathy which associates… 
Review
2013
Review
2013
Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal Disease
SUMMARY Neisseria meningitidis is a Gram-negative microorganism that exists exclusively in humans and can cause devastating… 
2011
2011
Molecular Characterization of the Interaction between Sialylated Neisseria gonorrhoeae and Factor H*
Human factor H (HufH), a key inhibitor of the alternative pathway of complement, binds to Neisseria gonorrhoeae and constitutes… 
Highly Cited
2009
Highly Cited
2009
Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome*
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy associated with mutations in complement proteins, most… 
Highly Cited
2008
Highly Cited
2008
Binding of the Long Pentraxin PTX3 to Factor H: Interacting Domains and Function in the Regulation of Complement Activation1
The long pentraxin PTX3 is a multifunctional soluble molecule involved in inflammation and innate immunity. As an acute phase… 
Highly Cited
2002
Highly Cited
2002
Acquisition of Regulators of Complement Activation by Streptococcus pyogenes Serotype M1
ABSTRACT Opsonization of bacteria by complement proteins is an important component of the immune response. The pathogenic… 
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