COMPLEMENT FACTOR H

Known as: Factor H, Complement, Factor H, h factor 
An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis… (More)
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Highly Cited
2011
Highly Cited
2011
Oxidative stress and enhanced lipid peroxidation are linked to many chronic inflammatory diseases, including age-related macular… (More)
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Highly Cited
2010
Highly Cited
2010
Age-related macular degeneration (AMD) is the predominant cause of blindness in the industrialized world where destruction of the… (More)
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Highly Cited
2009
Highly Cited
2009
Infections with enterohemorrhagic Escherichia coli (EHEC) are a major cause of hemolytic uremic syndrome (HUS). Shiga toxins… (More)
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Highly Cited
2009
Highly Cited
2009
Complement factor H (fH), a molecule that downregulates complement activation, binds to Neisseria meningitidis and increases… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE To determine the association between complement factor H (CFH) polymorphism T1277C (tyrosine-402 --> histidine-402) and… (More)
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Highly Cited
2007
Highly Cited
2007
Age-related macular degeneration is the most common form of legal blindness in westernized societies, and polymorphisms in the… (More)
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Highly Cited
2006
Highly Cited
2006
CONTEXT The evidence that inflammation is an important pathway in age-related macular degeneration (AMD) is growing. Recent case… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Variants in the complement factor H gene (CFH) are associated with age-related macular degeneration (AMD). CFH and… (More)
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Highly Cited
2000
Highly Cited
2000
Factor H (fH) restricts activation of the alternative pathway of complement at the level of C3, both in the fluid phase and on… (More)
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