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cobiprostone

Known as: Cyclopenta(b)pyran-5-heptanoic Acid, 2-((3S)-1,1-Difluoro-3-methylpentyl)octahydro-2-hydroxy-6-oxo-, (2R,4aR,5R,7aR)- 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Prostaglandins

Narrower (1)

SPI-8811

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Identification of the fatty acid activation site on human ClC-2.
Fatty acids (including lubiprostone and cobiprostone) are human ClC-2 (hClC-2) Cl- channel activators. Molecular and cellular… 
2015
2015
Cobiprostone Activates Human Bronchial Epithelial (HBE) Cell ClC‐2, but not CFTR
HBE cells contain both ClC‐2 and CFTR Cl‐ channels. The objective was to identify the Cl‐ channel in HBE cells that is activated… 
2011
2011
Avances en patología gastrointestinal relacionada con el tratamiento con antiinflamatorios no esteroideos y antiagregantes plaquetarios
2010
2010
475f Cobiprostone Demonstrates Protective Effects Against Non-Steroidal Anti-Inflammatory Drug (NSAID)-Induced Gastrointestinal Injury
2009
2009
Gastro‐protective Properties of Cobiprostone against Acid‐induced Mucosal Injury in Porcine Gastric Mucosa
Activation of ClC‐2 Cl− channels is an important mechanism of intestinal mucosal barrier repair. Lubiprostone, a prostone known… 
2009
2009
S1766 Cobiprostone Protects Against Indomethacin Damage Through Activation of Clc-2: A Gene Chip Analysis and Clc-2 Ablation Study
2008
2008
W1939 Effect of Cobiprostone On Naproxen-Induced Gastric Ulcers in Rats
2008
2008
W1738 Gastroprotective Properties of Cobiprostone Against Acid and NSAID-Induced Mucosal Injury in Porcine Gastric Mucosa
2007
2007
Effects of Cobiprostone on Indomethacin- and Stress-Induced Gastric Ulcers in Rats: 115
2007
2007
Cobiprostone Is a Type-2 Chloride Channel Activator That Protects Against NSAID-Induced Cellular Damage: 126
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