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Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine
TLDR
The permanent porcine intestinal epithelial cell line, IPEC-J2, is characterized using a variety of methods to assess the usefulness of this cell line as an in vitro infection model and concludes that it provides a relevant in vitro model system for porCine intestinal pathogen–host cell interactions.
Restoration of barrier function in injured intestinal mucosa.
TLDR
Ex vivo studies of mammalian small intestine have revealed the importance of closure of the interepithelial tight junctions and the paracellular space, which underscores the critical role of tight junction closure in measures of barrier function such as transepithelial electrical resistance.
Early weaning stress impairs development of mucosal barrier function in the porcine intestine.
TLDR
It is shown that stress associated with early weaning in pigs leads to impaired mucosal barrier function, and activation of mast cells ex vivo with c48/80 and corticotrophin-releasing factor induced barrier dysfunction and elevations in short-circuit current that were inhibited with mast cell protease inhibitors.
Type III Interferon Restriction by Porcine Epidemic Diarrhea Virus and the Role of Viral Protein nsp1 in IRF1 Signaling
TLDR
PEDV evasion of the type III IFN response in intestinal epithelial cells is shown for the first time, and it provides valuable information on host cell-virus interactions not only for PEDV but also for other enteric viral infections in swine.
Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig.
TLDR
The results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways.
Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs.
TLDR
The results indicate that early-weaning stress induces mucosal dysfunction mediated by intestinal mast cell activation and can be prevented by delaying weaning.
Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research.
TLDR
This review assesses animal models of ischemia-reperfusion injury as well as the knowledge that has been derived from each to aid selection of appropriate research models.
Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.
TLDR
Treatment with systemic lidocaine ameliorated the inhibitory effects of flunixin meglumine on recovery of the mucosal barrier from ischaemic injury, when the 2 treatments were combined.
Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum.
TLDR
It is suggested that IV administration of meloxicam may be a useful alternative to flunixin meglumine for postoperative treatment of horses with colic.
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