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SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents.
TLDR
It is demonstrated that SPI-0211 is a potent activator of ClC-2 Cl- channels and a physiologically relevant role for ClC/Cl- channels in intestinal Cl- transport after SPI- 0211 administration is suggested.
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Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets.
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Metal, Ceramic and Polymeric Composites for Various Uses
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Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
It has been difficult to separate/identify the roles of ClC-2 and CFTR in Cl(-) transport studies. Using pharmacological agents, we aimed to differentiate functionally between ClC-2 and CFTR Cl(-)…
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Nanocomposites with Unique Properties and Applications in Medicine and Industry
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Nanocomposites and Polymers with Analytical Methods
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Gastric parietal cell secretory membrane contains PKA- and acid-activated Kir2.1 K+ channels.
TLDR
Findings strongly suggest that the Kir2.1 K+ channel may be involved in regulated gastric acid secretion at the parietal cell secretory membrane.
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Cellular and molecular effects of unoprostone as a BK channel activator.
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ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole.
TLDR
The ClC-2 Cl- channel is identified as a potential target for therapy in cystic fibrosis and its function was assessed by measuring Cl- currents by patch clamp in the presence of a cAMP-dependent protein kinase (PKA) inhibitor, myristoylatedprotein kinase inhibitor, to prevent PKA-activated Cl- current.
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PKA and arachidonic acid activation of human recombinant ClC-2 chloride channels.
TLDR
An HEK-293 cell line stably expressing the human recombinant ClC-2 Cl(-) channel was used in patch-clamp studies to study its regulation and found it to be independent of PKA or protein kinase C activation.
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