cobicistat

Known as: 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate, 2,7,10,12-Tetraazatridecanoic acid, 12-methyl-13-(2-(1-methylethyl)-4-thiazolyl)-9-(2-(4-morpholinyl)ethyl)-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3R,6R,9S)-, Cobicistat [Chemical/Ingredient] 
A carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Tenofovir disoproxil fumarate can cause renal and bone toxic effects related to high plasma tenofovir concentrations… (More)
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2014
2014
Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular… (More)
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2013
2013
Cobicistat is a novel cytochrome P450 3A4 (CYP3A4) inhibitor in advanced clinical evaluation for use as a pharmacoenhancer of… (More)
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Highly Cited
2013
Highly Cited
2013
This ongoing, randomized, double-blind, active-controlled phase 3 international trial demonstrated the noninferior efficacy of… (More)
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Highly Cited
2013
Highly Cited
2013
We report week 96 results from a phase 3 trial of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (EVG/COBI… (More)
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2013
2013
BACKGROUND  Cobicistat (COBI) is a pharmacoenhancer with no antiretroviral activity in vitro. METHODS  An international… (More)
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Highly Cited
2012
Highly Cited
2012
OBJECTIVE This study evaluated the effect of cobicistat (COBI) on glomerular filtration rate in subjects with normal renal… (More)
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Highly Cited
2012
Highly Cited
2012
Highly Cited
2012
BACKGROUND The HIV integrase strand transfer inhibitor elvitegravir (EVG) has been co-formulated with the CYP3A4 inhibitor… (More)
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2010
2010
Cobicistat (3, GS-9350) is a newly discovered, potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes. In… (More)
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