University College London, University College London Hospitals NHS Foundation Trust, London, UK
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Real-time RT-PCR normalisation; strategies and considerations
Real-time RT-PCR has become a common technique, no longer limited to specialist core facilities. It is in many cases the only method for measuring mRNA levels of vivo low copy number targets of… Expand
The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China
- D. Hui, Esam I Azhar, +9 authors E. Petersen
- International Journal of Infectious Diseases
- 14 January 2020
The city of Wuhan in China is the focus of global attention due to an outbreak of a febrile respiratory illness due to a coronavirus 2019-nCoV. In December 2019, there was an outbreak of pneumonia of… Expand
Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study
Summary Background Middle East respiratory syndrome (MERS) is a new human disease caused by a novel coronavirus (CoV). Clinical… Expand
Hospital outbreak of Middle East respiratory syndrome coronavirus.
BACKGROUND In September 2012, the World Health Organization reported the first cases of pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERS-CoV). We describe a cluster of… Expand
Coronaviruses — drug discovery and therapeutic options
- Alimuddin Zumla, J. F. Chan, E. I. Azhar, D. Hui, K. Yuen
- Biology, Medicine
- Nature Reviews Drug Discovery
- 12 February 2016
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract infections, such as the… Expand
Validation of housekeeping genes for normalizing RNA expression in real-time PCR.
- K. Dheda, J. Huggett, S. Bustin, M. Johnson, G. Rook, Alimuddin Zumla
- Biology, Medicine
- 1 July 2004
Analysis of RNA expression using techniques like real-time PCR has traditionally used reference or housekeeping genes to control for error between samples. This practice is being questioned as it… Expand
Advances in the development of new tuberculosis drugs and treatment regimens
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid, rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to cause… Expand
The WHO 2014 global tuberculosis report--further to go.
- Alimuddin Zumla, A. George, V. Sharma, Rt Hon Nick Herbert, A. Oxley, M. Oliver
- The Lancet. Global health
This article discusses how the 19th WHO global tuberculosis report 2014 provides an opportunity to think about the global tuberculosis strategy, and to assess just how much further effort is needed… Expand
Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis.
- J. Caminero, G. Sotgiu, Alimuddin Zumla, Giovanni Battista Migliori
- The Lancet. Infectious diseases
- 1 September 2010
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis are generally thought to have high mortality rates. However, many cases can be treated with the right combination and… Expand
Epidemiology and clinical management of Legionnaires' disease.
Legionnaires' disease is an important cause of community-acquired and hospital-acquired pneumonia. Although uncommon, Legionnaires' disease continues to cause disease outbreaks of public health… Expand