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cidofovir hexadecyloxypropyl ester

Known as: HDP-Cidofovir, HDP-CDV, Hexadecyloxypropyl-Cidofovir 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

CMX001brincidofovir

Broader (2)

CytosineOrganophosphonates
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Synthesis and Early Development of Hexadecyloxypropylcidofovir: An Oral Antipoxvirus Nucleoside Phosphonate
Hexadecyloxypropyl-cidofovir (HDP-CDV) is a novel ether lipid conjugate of (S)-1-(3-hydroxy-2-phosphonoylmethoxypropyl)-cytosine… 
Highly Cited
2010
Highly Cited
2010
1-O-Hexadecyloxypropyl Cidofovir (CMX001) Effectively Inhibits Polyomavirus BK Replication in Primary Human Renal Tubular Epithelial Cells
ABSTRACT Antiviral drugs for treating polyomavirus BK (BKV) replication in polyomavirus-associated nephropathy or hemorrhagic… 
Highly Cited
2009
Highly Cited
2009
Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art.
Highly Cited
2007
Highly Cited
2007
Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses
ABSTRACT The combination of ST-246 and hexadecyloxypropyl-cidofovir or CMX001 was evaluated for synergistic activity in vitro… 
2006
2006
Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro.
2004
2004
Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice.
Review
2004
Review
2004
Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections
Several nucleoside and nucleotide analogues have been identified as potent antiviral agents with convincing activity against… 
2004
2004
Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir.
PURPOSE In an earlier study, a novel intraocular drug-delivery system was reported in which hexadecyloxypropyl-phospho… 
Highly Cited
2003
Highly Cited
2003
Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.
Recently, there has been renewed interest in finding orally active drugs against smallpox. Cidofovir (CDV) given by parenteral… 
Highly Cited
2003
Highly Cited
2003
Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.
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