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A three-dimensional model to analyze drug-drug interactions.
Valganciclovir for symptomatic congenital cytomegalovirus disease.
Treating symptomatic congenital CMV disease with valganciclovir for 6 months, as compared with 6 weeks, did not improve hearing in the short term but appeared to improve hearing and developmental outcomes modestly in the longer term.
A review of genetic differences between limited and extensively passaged human cytomegalovirus strains
It is hypothesized that this plasticity of the genome at the right edge of the unique long (UL) component of the UL component results from extensive passage and adaptation to replication in fibroblasts in vitro.
Host Immune System Gene Targeting by a Viral miRNA
It is shown that hcmv-miR-UL112 specifically down-regulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells, revealing a miRNA-based immunoevasion mechanism that appears to be exploited by human cytomegalovirus.
Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus.
Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidation.
- D. Wolf, C. T. Courcelle, M. Prichard, E. Mocarski
- BiologyProceedings of the National Academy of Sciences…
- 13 February 2001
The function of UL97 in DNA synthesis as well as capsid assembly suggests that protein phosphorylation mediated by this herpesvirus-conserved kinase increases the efficiency of these two distinct phases of virus replication.
Analysis of Human Cytomegalovirus-Encoded MicroRNA Activity during Infection
- Noam Stern-Ginossar, N. Saleh, Miri D Goldberg, M. Prichard, D. Wolf, O. Mandelboim
- BiologyJournal of Virology
- 5 August 2009
It is demonstrated that a human cytomegalovirus-encoded miRNA, miR-UL112, also targets the UL114 gene, and evidence is presented that the reduction of UL114 by miR -UL112 reduces its activity as uracil DNA glycosylase but only minimally affects virus growth.
Human Cytomegalovirus UL97 Kinase Is Required for the Normal Intranuclear Distribution of pp65 and Virion Morphogenesis
It is proposed that the kinase plays an important role in the acquisition of tegument during virion morphogenesis in the nucleus and that this activity represents an important step in the production of mature virus particles.
Human Cytomegalovirus UL97 Kinase Activity Is Required for the Hyperphosphorylation of Retinoblastoma Protein and Inhibits the Formation of Nuclear Aggresomes
It is concluded that both UL97 kinase activity and the LxCxE RB binding motif are required for the phosphorylation and stabilization of RB in infected cells and that this effect can be antagonized by the antiviral drug maribavir.
Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir
- M. Prichard
- Biology, ChemistryReviews in medical virology
- 1 July 2009
The critical functions performed by the UL97 kinase illustrate its importance in viral replication and confirm that the kinase is a target for the development of antiviral therapies.