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chromatin silencing at telomere

Known as: heterochromatic silencing at telomere, telomere chromatin silencing, telomeric silencing 
Repression of transcription of telomeric DNA by altering the structure of chromatin. [PMID:10219245]
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

chromatin silencing
chromosome, telomeric regionnegative regulation of chromatin silencing at telomere

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Conserved Histone Variant H2A.Z Protects Euchromatin from the Ectopic Spread of Silent Heterochromatin
Boundary elements hinder the spread of heterochromatin, yet these sites do not fully account for the preservation of adjacent… Expand
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Highly Cited
2003
Highly Cited
2003
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.
Ubiquitination of histone H2B catalyzed by Rad6 is required for methylation of histone H3 by COMPASS. We identified Bre1 as the… Expand
Highly Cited
2002
Highly Cited
2002
Dot1p Modulates Silencing in Yeast by Methylation of the Nucleosome Core
DOT1 was originally identified as a gene affecting telomeric silencing in S. cerevisiae. We now find that Dot1p methylates… Expand
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Highly Cited
2002
Highly Cited
2002
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
The amino-terminal histone tails are subject to covalent post-translational modifications such as acetylation, methylation, and… Expand
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Highly Cited
2000
Highly Cited
2000
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
The yeast Sir2 protein, required for transcriptional silencing, has an NAD(+)-dependent histone deacetylase (HDA) activity. Yeast… Expand
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Highly Cited
1998
Highly Cited
1998
Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.
The ends of chromosomes in Saccharomyces cerevisiae initiate a repressive chromatin structure that spreads internally and… Expand
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Highly Cited
1998
Highly Cited
1998
Components of the Ku‐dependent non‐homologous end‐joining pathway are involved in telomeric length maintenance and telomeric silencing
In the budding yeast, Saccharomyces cerevisiae, genes in close proximity to telomeres are subject to transcriptional silencing… Expand
Highly Cited
1997
Highly Cited
1997
Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I.
In vivo, nucleosomes are formed rapidly on newly synthesized DNA after polymerase passage. Previously, a protein complex from… Expand
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Highly Cited
1995
Highly Cited
1995
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.
Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of… Expand
Highly Cited
1994
Highly Cited
1994
Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.
Genes located near telomeres in yeast are subject to position-effect variegation. To better understand the mechanism of this… Expand
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