• Corpus ID: 19240562

Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast.

@article{Longhese2000CheckpointPI,
  title={Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast.},
  author={Maria Pia Longhese and Vera Paciotti and H Neecke and Giovanna Lucchini},
  journal={Genetics},
  year={2000},
  volume={155 4},
  pages={
          1577-91
        }
}
A complex network of surveillance mechanisms, called checkpoints, interrupts cell cycle progression when damage to the genome is detected or when cells fail to complete DNA replication, thus ensuring genetic integrity. In budding yeast, components of the DNA damage checkpoint regulatory network include the RAD9, RAD17, RAD24, MEC3, DDC1, RAD53, and MEC1 genes that are proposed to be involved in different aspects of DNA metabolism. We provide evidence that some DNA damage checkpoint components… 

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Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae
  • K. Myung, R. Kolodner
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
TLDR
Low doses of methyl methane sulfonate that activate the intra-S checkpoint but not the G1 or G2 DNA damage checkpoints were found to cause increased accumulation of genome rearrangements and indicate that there is a high degree of redundancy among the checkpoints that act in S phase to suppress such genome instability.
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TLDR
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TLDR
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