Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast.

@article{Longhese2000CheckpointPI,
  title={Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast.},
  author={Maria Pia Longhese and Vera Paciotti and H Neecke and G. Lucchini},
  journal={Genetics},
  year={2000},
  volume={155 4},
  pages={1577-91}
}
A complex network of surveillance mechanisms, called checkpoints, interrupts cell cycle progression when damage to the genome is detected or when cells fail to complete DNA replication, thus ensuring genetic integrity. In budding yeast, components of the DNA damage checkpoint regulatory network include the RAD9, RAD17, RAD24, MEC3, DDC1, RAD53, and MEC1 genes that are proposed to be involved in different aspects of DNA metabolism. We provide evidence that some DNA damage checkpoint components… CONTINUE READING

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