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cholylsarcosine

Known as: Glycine, N-methyl-N-((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)- 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Cholic AcidsSarcosine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
[N-Methyl-11C]Cholylsarcosine, a Novel Bile Acid Tracer for PET/CT of Hepatic Excretory Function: Radiosynthesis and Proof-of-Concept Studies in Pigs
Excretion of conjugated bile acids into bile is an essential function of the liver, and impairment of canalicular bile acid… Expand
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Review
2009
Review
2009
Bile-acid-induced cell injury and protection.
Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of… Expand
2004
2004
Adjuvant Cholylsarcosine During Ursodeoxycholic Acid Treatment of Primary Biliary Cirrhosis
We postulated that coadministration ofcholylsarcosine with ursodeoxycholic acid might provideadditional benefit to primary… Expand
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Highly Cited
2003
Highly Cited
2003
Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats
Experiments were performed to test whether conjugated bile acid administration would decrease bacterial overgrowth, bacterial… Expand
2000
2000
Improvement of intestinal peptide absorption by a synthetic bile acid derivative, cholylsarcosine.
The potential of the nontoxic bile salt derivative, cholylsarcosine, to enhance the intestinal absorption of peptides was… Expand
Highly Cited
1999
Highly Cited
1999
Bile acid replacement therapy with cholylsarcosine for short-bowel syndrome.
BACKGROUND Fat malabsorption in the short-bowel syndrome (SBS) may in part be caused by decreased bile secretion. Cholylsarcosine… Expand
1993
1993
Cholylsarcosine, a new bile acid analogue: metabolism and effect on biliary secretion in humans.
BACKGROUND Cholylsarcosine, the synthetic conjugate of cholic acid and sarcosine, is resistant to deconjugation-dehydroxylation… Expand
Highly Cited
1993
Highly Cited
1993
Negative feedback regulation of the ileal bile acid transport system in rodents.
BACKGROUND Active transport of conjugated bile acids by ileal enterocytes is a key mechanism for conservation of the bile acid… Expand
1992
1992
Physicochemical and physiological properties of cholylsarcosine. A potential replacement detergent for bile acid deficiency states in the small intestine.
The properties of cholylsarcosine (the synthetic N-acyl conjugate of cholic acid with sarcosine [N-methylglycine]) were examined… Expand
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1990
1990
Transport, metabolism, and effect of chronic feeding of cholylsarcosine, a conjugated bile acid resistant to deconjugation and dehydroxylation.
To test the effect in rodents of chronic ingestion of a bile acid resistant to deconjugation, cholylsarcosine was synthesized and… Expand
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