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The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
TLDR
A simple scoring system accurately separates patients with nonalcoholic fatty liver disease with and without advanced fibrosis, rendering liver biopsy for identification ofAdvanced fibrosis unnecessary in a substantial proportion of patients.
The natural history of nonalcoholic fatty liver disease: a population-based cohort study.
TLDR
Mortality among community-diagnosed NAFLD patients is higher than the general population and is associated with older age, impaired fasting glucose, and cirrhosis, although the absolute risk is low.
Immunoglobulin G4-associated cholangitis: clinical profile and response to therapy.
TLDR
IAC should be suspected in unexplained biliary strictures associated with increased serum IgG4 and unexplained pancreatic disease, especially with proximal strictures, and the role of immunomodulatory drugs for relapses needs further study.
Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
TLDR
Older age, obesity, and presence of diabetes mellitus help identify those NASH patients who might have severe liver fibrosis, and this is the subgroup of patients who would be expected to derive the most benefit from having a liver biopsy and considering investigational therapies.
Association of Non-alcoholic Fatty Liver Disease with Chronic Kidney Disease: A Systematic Review and Meta-analysis
TLDR
In a systematic review and meta-analysis, Giovanni Musso and colleagues examine the association between non-alcoholic fatty liver disease and chronic kidney disease and finds no clear link between the two.
Risk factors and comorbidities in primary biliary cirrhosis: A controlled interview‐based study of 1032 patients
TLDR
Environmental factors, possibly including infectious agents through urinary tract infections or chemicals contained in cigarette smoke, may induce PBC in genetically susceptible individuals and exogenous estrogens may also contribute to explain the female predominance of the disease.
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
TLDR
Current understanding of this enigmatic disorder is reviewed, the recognition of specific clinical subtypes and their pattern of progression could improve phenotypic and genotypic classification of the disease, and important topics for future studies are discussed.
Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis.
TLDR
UDCA significantly decreases the risk of developing colorectal dysplasia or cancer in patients with UC and PSC in a randomized, placebo-controlled trial.
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