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choline biosynthetic process

Known as: choline biosynthesis, choline anabolism, choline synthesis 
The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the… Expand
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Highly Cited
2010
Highly Cited
2010
Phosphatidic acid phosphohydrolase 1 and 2 regulate phospholipid synthesis at the endoplasmic reticulum in Arabidopsis.
Phospholipid biosynthesis is essential for the construction of most eukaryotic cell membranes, but how this process is regulated… Expand
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Review
2006
Review
2006
Choline Transport for Phospholipid Synthesis
Choline is an essential nutrient for all cells because it plays a role in the synthesis of the membrane phospholipid components… Expand
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Highly Cited
2005
Highly Cited
2005
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans.
Choline is a required nutrient, and some humans deplete quickly when fed a low-choline diet, whereas others do not. Endogenous… Expand
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2005
2005
Phosphatidylcholine and lysophosphatidylcholine excretion is increased in children with cystic fibrosis and is associated with plasma homocysteine, S-adenosylhomocysteine, and S-adenosylmethionine.
BACKGROUND Hepatic steatosis and fat malabsorption are common in cystic fibrosis (CF). Choline deficiency results in decreased… Expand
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2000
2000
Radiotracer and computer modeling evidence that phospho-base methylation is the main route of choline synthesis in tobacco.
Among flowering plants, the synthesis of choline (Cho) from ethanolamine (EA) can potentially occur via three parallel… Expand
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1994
1994
In vitro and in vivo 13C and 31P NMR analyses of phosphocholine metabolism in rat glioma cells.
In vivo magnetic resonance spectroscopy (MRS) has revealed that phosphomonoesters (PME) such as phosphocholine (PCho) and… Expand
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1994
1994
P2u purinoceptor stimulation of surfactant secretion coupled to phosphatidylcholine hydrolysis in type II cells.
ATP is known to stimulate surfactant phospholipid secretion in type II cells, and there is evidence that this effect is mediated… Expand
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1991
1991
Formation of Free Choline in Brain Tissue during in vitro Energy Deprivation
Free choline and ATP contents were measured in Mongolian gerbil hippocampal slices (tissue) and incubation media (media) during… Expand
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Highly Cited
1987
Highly Cited
1987
Synthesis of acetylcholine from choline derived from phosphatidylcholine in a human neuronal cell line.
Cholinergic neurons are unique among cells since they alone utilize choline not only as a component of major membrane… Expand
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