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chelerythrine chloride

 
National Institutes of Health

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chelerythrine

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Highly Cited
2005
Highly Cited
2005
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
Pain, a critical component of host defense, is one hallmark of the inflammatory response. We therefore hypothesized that pain… Expand
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Highly Cited
2001
Highly Cited
2001
Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice.
Stem cell homing into the bone microenvironment is the first step in the initiation of marrow-derived blood cells. It is reported… Expand
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Highly Cited
2001
Highly Cited
2001
Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways
Objective We tested the hypothesis that increased responsiveness of phospholipase D (PLD) to angiotensin II (Ang II) is… Expand
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Highly Cited
2001
Highly Cited
2001
Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function*
The Rho-GDP guanine nucleotide dissociation inhibitor (GDI) complexes with the GDP-bound form of Rho and inhibits its activation… Expand
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Highly Cited
2000
Highly Cited
2000
In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.
Although clonogenic or divisional death is the main mechanism by which DNA-damaging agents demonstrate antitumor activity, recent… Expand
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Highly Cited
2000
Highly Cited
2000
Basic Fibroblast Growth Factor Inhibits Apoptosis of Spontaneously Immortalized Granulosa Cells by Regulating Intracellular Free Calcium Levels through a Protein Kinase Cδ-Dependent Pathway* * This…
Previous studies have shown that basic fibroblast growth factor (bFGF) inhibits primary granulosa cells from undergoing apoptosis… Expand
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Highly Cited
1998
Highly Cited
1998
Evidence of ζ Protein Kinase C Involvement in Polymorphonuclear Neutrophil Integrin-dependent Adhesion and Chemotaxis*
Classical chemoattractants and chemokines trigger integrin-dependent adhesion of blood leukocytes to vascular endothelium and… Expand
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Highly Cited
1997
Highly Cited
1997
Glucose-Induced Protein Kinase C Activation Regulates Vascular Permeability Factor mRNA Expression and Peptide Production by Human Vascular Smooth Muscle Cells In Vitro
Hyperglycemia is an independent risk factor for the development of diabetic microvascular disease. Vascular permeability factor… Expand
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Highly Cited
1997
Highly Cited
1997
Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn.
Nocturnal synthesis of the pineal hormone melatonin (MEL) is regulated by the circadian clock in the suprachiasmatic nucleus (SCN… Expand
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1990
1990
Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans.
Chelerythrine chloride is an antiplatelet agent isolated from Zanthoxylum simulans. Aggregation and ATP release of washed rabbit… Expand
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