chelerythrine chloride

 
National Institutes of Health

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chelerythrine

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2011
2011
Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell.
The objective of this study was to evaluate the antitumor activity of chelerythrine chloride (CHE) and investigate its potential… (More)
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Highly Cited
2005
Highly Cited
2005
Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling.
Previous studies have reported the sex differences in heart susceptibility to ischemia/reperfusion (I/R) injury, but the… (More)
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Highly Cited
2005
Highly Cited
2005
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
Pain, a critical component of host defense, is one hallmark of the inflammatory response. We therefore hypothesized that pain… (More)
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Highly Cited
2001
Highly Cited
2001
Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice.
Stem cell homing into the bone microenvironment is the first step in the initiation of marrow-derived blood cells. It is reported… (More)
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Highly Cited
2001
Highly Cited
2001
Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function.
The Rho-GDP guanine nucleotide dissociation inhibitor (GDI) complexes with the GDP-bound form of Rho and inhibits its activation… (More)
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Highly Cited
2001
Highly Cited
2001
Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways.
OBJECTIVE We tested the hypothesis that increased responsiveness of phospholipase D (PLD) to angiotensin II (Ang II) is… (More)
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2000
2000
In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.
Although clonogenic or divisional death is the main mechanism by which DNA-damaging agents demonstrate antitumor activity, recent… (More)
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Highly Cited
1999
Highly Cited
1999
Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium.
Growing evidence exists that ATP-sensitive mitochondrial potassium channels (MitoKATP channel) are a major contributor to the… (More)
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Highly Cited
1998
Highly Cited
1998
Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.
Classical chemoattractants and chemokines trigger integrin-dependent adhesion of blood leukocytes to vascular endothelium and… (More)
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Highly Cited
1997
Highly Cited
1997
Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawn.
Nocturnal synthesis of the pineal hormone melatonin (MEL) is regulated by the circadian clock in the suprachiasmatic nucleus (SCN… (More)
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