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checkpoint kinase 2

Known as: Protein Kinase, Chk2, Kinase, PP1425 Protein, Kinase CHK2, Serine-Threonine-Protein 
Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1… 
National Institutes of Health

Related topics

Related topics

12 relations
CHEK2 geneIn BloodProcess of secretionantagonists & inhibitors

Narrower (4)

CHEK2 protein, humanCds1 protein, S pombeChek2 protein, ratrad3 protein, S pombe

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Negative Regulation von Hormonsensibilität und Proliferation von Prostatakarzinomzellen
2016
2016
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) regulates the expression of polo- like kinase 1 (PLK1) through competitive interaction with microRNA-149-3p
2014
2014
In vivo role of checkpoint kinase 2 in signaling telomere dysfunction
Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to… 
2014
2014
Distinct DNA damage determines differential phosphorylation of Chk2
Checkpoint kinase 2 (Chk2) has been implicated in DNA damage signaling. By using BJ human fibroblasts, HCT116 colorectal cancer… 
2014
2014
Abstract 3758: Inhibition of ATR, but not ATM, sensitizes gynecologic cancer cells to cisplatin
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Resistance to platinum-based therapies remains a major… 
2013
2013
The Co-Repressor SMRT Delays DNA Damage-Induced Caspase Activation by Repressing Pro-Apoptotic Genes and Modulating the Dynamics of Checkpoint Kinase 2 Activation
Checkpoint kinase 2 (Chk2) is a major regulator of DNA damage response and can induce alternative cellular responses: cell cycle… 
2012
2012
Molecular mechanisms of anti-proliferative effects of the Traditional Chinese Medicinal compound Rocaglamide A on cancers
Die Fehlregulation des Zellzyklus ist eine von zehn beschriebenen Merkmalen von Krebs. Daher ist eine vielversprechende Strategie… 
2011
2011
DNA Damage Response is Prominent in Ovarian High-Grade Serous Carcinomas, Especially Those with Rsf-1 (HBXAP) Overexpression
DNA damage commonly occurs in cancer cells as a result of endogenous and tumor microenvironmental stress. In this study, we… 
2010
2010
DNA damage responses in human pluripotent stem cells
Pluripotent stem cells have the capability to undergo unlimited self-renewal and differentiation into all somatic cell types… 
Highly Cited
2006
Highly Cited
2006
Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
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