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ceramide biosynthetic process

Known as: ceramide formation, ceramide biosynthesis, ceramide anabolism 
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. [GOC:ai]
National Institutes of Health

Related topics

Related topics

1 relation
negative regulation of ceramide biosynthetic process

Papers overview

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Review
2007
Review
2007
Life and death decisions of the pancreatic beta-cell: the role of fatty acids.
Both stimulatory and detrimental effects of NEFAs (non-esterified fatty acids) on pancreatic beta-cells have been recognized… 
2007
2007
Mechanism of Homocysteine-Induced Rac1/NADPH Oxidase Activation in Mesangial Cells: Role of Guanine Nucleotide Exchange Factor Vav2
We have demonstrated that homocysteine (Hcys) stimulates de novo ceramide synthesis and thereby induces NADPH oxidase activation… 
Highly Cited
2004
Highly Cited
2004
Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion.
Prolonged exposure to elevated levels of fatty acids adversely affects pancreatic beta-cell function. Here we investigated 1… 
2004
2004
Singlet Oxygen-induced Attenuation of Growth Factor Signaling: Possible Role of Ceramides
Singlet oxygen, an electronically excited form of molecular oxygen, is a primary mediator of the activation of stress-activated… 
Highly Cited
2003
Highly Cited
2003
Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae*
Long chain sphingoid bases (LCBs) and their phosphates (LCBPs) are not only important intermediates in ceramide biosynthesis but… 
Highly Cited
2003
Highly Cited
2003
Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel.
Recent studies demonstrated that the resistance of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL… 
Highly Cited
1998
Highly Cited
1998
Apoptosis and Activation of the Sphingomyelin-Ceramide Pathway Induced by Oxidized Low Density Lipoproteins Are Not Causally Related in ECV-304 Endothelial Cells*
Oxidized low density lipoproteins (oxLDL) are thought to play a central role in the development of atherosclerosis. Toxic… 
Highly Cited
1997
Highly Cited
1997
Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling.
The chemotherapeutic agent CPT-11 induced apoptotic cell death in mouse fibroblast 4B1 cells. To examine the intracellular… 
1997
1997
Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin‐ceramide pathway in human macrophages
Highly Cited
1979
Highly Cited
1979
Synthesis of ceramides and cerebrosides containing both alpha-hydroxy and nonhydroxy fatty acids from lignoceroyl-CoA by rat brain microsomes.
The conversion of [1-14C]lignoceroyl-CoA to nonhydroxy- and alpha-hydroxyceramides and cerebrosides by brain microsomes of… 
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