ceramide biosynthetic process

Known as: ceramide formation, ceramide biosynthesis, ceramide anabolism 
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. [GOC:ai]
National Institutes of Health

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negative regulation of ceramide biosynthetic process

Papers overview

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Highly Cited
2011
Highly Cited
2011
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes… (More)
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Review
2010
Review
2010
Ceramide in suicidal death of erythrocytes.
The suicidal death of erythrocytes or eryptosis is characterized by cell shrinkage, membrane blebbing and cell membrane… (More)
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Highly Cited
2008
Highly Cited
2008
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy.
Ceramide is among a number of potential lipotoxic molecules that are thought to modulate cellular energy metabolism. The heart is… (More)
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Highly Cited
2007
Highly Cited
2007
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance.
Insulin resistance occurs in 20%-25% of the human population, and the condition is a chief component of type 2 diabetes mellitus… (More)
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Highly Cited
2006
Highly Cited
2006
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells.
Accumulation of lipids in nonadipose tissues can lead to cell dysfunction and cell death, a phenomenon known as lipotoxicity… (More)
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Highly Cited
2004
Highly Cited
2004
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide
Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF… (More)
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Review
2003
Review
2003
Ceramide: second messenger or modulator of membrane structure and dynamics?
The physiological role of ceramide formation in response to cell stimulation remains controversial. Here, we emphasize that… (More)
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Highly Cited
2001
Highly Cited
2001
Palmitate-induced apoptosis can occur through a ceramide-independent pathway.
Cytotoxic accumulation of long chain fatty acids has been proposed to play an important role in the pathogenesis of diabetes… (More)
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Highly Cited
1998
Highly Cited
1998
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.
Like obese humans, Zucker diabetic fatty (ZDF) rats exhibit early beta cell compensation for insulin resistance (4-fold beta cell… (More)
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Highly Cited
1997
Highly Cited
1997
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis.
To identify cell death-induced genes, we employed a subtractive hybridization approach and isolated a cDNA encoding a mouse… (More)
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