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The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells
It is confirmed that mir-34 is required for a normal cellular response to DNA damage in vivo resulting in altered cellular survival post-irradiation, and point to a potential therapeutic use for anti-miR-34 as a radiosensitizing agent in p53-mutant breast cancer. Expand
Expression of epithelial-cadherin, alpha-catenin and beta-catenin during human intrahepatic bile duct development: a possible role in bile duct morphogenesis.
The results suggest that E-Cad, A-Cat and B-Cat are involved in the normal developmental morphogenesis of human intrahepatic bile ducts. Expand
Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer
E-cadherin is a central molecule in the process of gastric carcinogenesis and its posttranslational modifications by N-glycosylation have been described to induce a deleterious effect on cellExpand
Relationship between hepatocyte necrosis, proliferation, and initiation induced by diethylnitrosamine in the male F344 rat.
The temporal pattern changes following 150 mg DEN/kg body wt are consistent with the attribution of regenerative cell proliferation contributing to the yield of initiated cells. Expand
Loss of expression of transforming growth factor beta type I and type II receptors correlates with tumor grade in human prostate cancer tissues.
  • I. Kim, H. Ahn, +8 authors C. Lee
  • Medicine
  • Clinical cancer research : an official journal of…
  • 1 August 1996
It is indicated that human prostate cancer cells frequently have loss of expression of TGF-beta type I and/or type II receptors, which provides a potential mechanism for prostate cancer Cells to escape the growth-inhibitory effect of T GF-beta. Expand
NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression
It is proposed that Nox1 mediates oncogenic Ras-induced upregulation of VEGF and angiogenesis by activating Sp1 through Ras-ERK-dependent phosphorylation of Sp1, and may act in concert with other effectors integrated into the Ras network. Expand
Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling.
Ceramide synthesis acts as a dominant regulator in CPT-11-initiated death signaling and sequentially operates the ICE cascade, suggesting the involvement of ceramide in ICE cascade operation. Expand
Pathological characterization of astrocytic hyaline inclusions in familial amyotrophic lateral sclerosis.
Evidence is provided that Ast-HIs are formed in certain long-surviving familial amyotrophic lateral sclerosis patients with neuronal Lewy-body-like hyaline inclusions and a cooperative role of superoxide dismutase 1, ubiquitin, and cytoskeletal proteins in the formation of granule-coated fibrils is suggested. Expand
Comparative immunohistochemical study on the expression of αB crystallin, ubiquitin and stress‐response protein 27 in ballooned neurons in various disorders
The results suggest that the mechanisms involved in formation and maintenance of swollen neurons in Pick's disease and CJD may be different than those of ballooned neurons in the other entities studied. Expand
Accumulation of murine amyloidβ42 in a gene‐dosage‐dependent manner in PS1 ‘knock‐in’ mice
The establishment of ‘knock‐in’ mice with the I213T PS1 missense mutation indicates that the level of the mutated PS1 gene expression is likely to be critically involved in the production of highly amyloidogenic Aβ42(43), and confirms that PS1 mutation has an important effect on amyloids precursor protein (APP) processing, in proportion to thelevel of the expression of the mutant gene. Expand