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centpropazine

Known as: 1-(4-(2-hydroxy-3-(4-phenylpiperazin-1-yl)-propoxy)phenyl)propan-1-one 
National Institutes of Health

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Piperazines

Papers overview

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2004
2004
Evaluation of pharmacokinetics, brain levels and protein binding of centpropazine in rats
The pharmacokinetics of centpropazine (CNPZ), an antidepressant, was studied in rats. CNPZ was administered to groups of rats (n… 
2002
2002
Isolation and characterization of metabolites of centpropazine in rat liver, intestine, and red blood cell homogenates.
The potential sites for metabolism of centpropazine (CPZ) (an antidepressant) were evaluated in male Sprague-Dawley rats. The… 
2001
2001
Evaluation of absorbability of centpropazine in rats: in‐situ and in‐vivo approaches
Intestinal absorption of centpropazine was studied in rats by both in‐situ (closed‐loop method) and in‐vivo (portal‐venous… 
1999
1999
MULTICENTRIC EFFICACY STUDY OF CENTPROPAZINE AND IMIPRAMINE IN DEPRESSED PATIENTS
Centpropazine is a new antidepressant with minimal anticholinergic effects in preclinical animal models. In this study… 
1999
1999
Development and validation of a new high-performance liquid chromatographic assay of centpropazine, a new antidepressant compound, in serum.
1993
1993
Centpropazine affinity to cortical noradrenergic receptors and effect on their responsiveness in the rat *
Abstract— We have studied the in‐vitro effect of centpropazine on cerebral cortical noradrenergic receptors measured as the… 
1992
1992
CLINICAL EFFICACY OF CENTPROPAZINE - A NEW ANTIDEPRESSANT
GUR-Efficacy of centpropazine, a new antidepressant, hasbeen evaluated in fortytwo patientsof'endogenous depression. The 4 week… 
1989
1989
Clinical pharmacological studies on centpropazine--a new antidepressant compound.
: Single oral doses of 10 to 160 mg centpropazine, a new antidepressant (synthesized by CDRI, Lucknow, India) were administered… 
1989
1989
Clinical pharmacological studies on centpropazine--a new antidepressant compound.
Single oral doses of 10 to 160 mg centpropazine, a new antidepressant (synthesized by CDRI, Lucknow, India) were administered to… 
1986
1986
Studies on centpropazine, a new antidepressant compound : part I assay.
Procedures for the assay of Centpropazine, a new antidepressant agent using spectrophotometry and HPLC are described. The… 
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