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Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
- Vaishali Bane, M. Lehane, M. Dikshit, A. O’Riordan, A. Furey
- Chemistry, Medicine
- 1 February 2014
Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which… Expand
Profile of acetylcholinesterase in brain areas of male and female rats of adult and old age.
Inhibition of acetylcholinesterase (AChE)-metabolizing enzyme of acetylcholine, is presently the most important therapeutic target for development of cognitive enhancers. However, AChE activity in… Expand
Piper betle Linn. a maligned Pan-asiatic plant with an array of pharmacological activities and prospects for drug discovery
Piper betle L. is one of the important plants in the Asiatic region which ranks second to coffee and tea in terms of daily consumption. Though the plant is known for abuse, in recent years several… Expand
Modulation of polymorphonuclear leukocytes function by nitric oxide.
Recognition of the endothelium-derived relaxation factor as nitric oxide (NO) gave rise to an impression that NO was synthesised only by the endothelial lining of the vessel wall. Later it was found… Expand
Contribution of genomics and proteomics in understanding the role of modifying factors in Parkinson's disease.
- M. P. Singh, S. Patel, M. Dikshit, Y. Gupta
- Biology, Medicine
- Indian journal of biochemistry & biophysics
- 1 April 2006
Parkinson's disease (PD) is a complex neurological disorder, characterized by selective degeneration of nigrostriatal dopaminergic neurons. It is a multi-factorial disease, contributed by a… Expand
Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats.
The present investigation was undertaken to suggest the involvement of free radicals in the pathogenesis of pyloric ligation induced ulcers in rats. Lipid peroxidation product (MDA), antioxidant… Expand
Anti-thrombotic effect of curcumin.
Prevention of ischaemia-induced biochemical changes by curcumin & quinidine in the cat heart.
Effect of myocardial ischaemia on the bioantioxidants levels in the cat heart was evaluated. In addition, effect of curcumin, an anti-inflammatory and anti-thrombotic drug, and quinidine, a standard… Expand
Ascorbate‐mediated enhancement of reactive oxygen species generation from polymorphonuclear leukocytes: modulatory effect of nitric oxide
- P. Sharma, S. A. Raghavan, R. Saini, M. Dikshit
- Biology, Medicine
- Journal of leukocyte biology
- 1 June 2004
Recent studies from our laboratory have demonstrated that ascorbate potentiated enzymatic synthesis of nitric oxide (NO) from polymorphonuclear leukocytes (PMNs). NO is known to modulate various… Expand
Role of molecular isoforms of acetylcholinesterase in learning and memory functions
In the present study, activity of salt soluble (SS) G1 and detergent soluble (DS) G4 molecular isoforms of acetylcholinesterase (AChE) has been investigated in rat brain areas in trained (learned),… Expand