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Screening of Indian plants for biological activity: I.
In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica.
Results indicate that asiaticoside exhibits significant wound healing activity in normal as well as delayed healing models and is the main active constituent of Centella asiaticsa. Expand
Asiaticoside‐induced elevation of antioxidant levels in healing wounds
It appears from the present study that asiaticosides enhanced induction of antioxidant levels at an initial stage of healing which may be an important contributory factor in the healing properties of this substance. Expand
Screening of Indian plants for biological activity: Part IX.
Antihepatotoxic properties of picroliv: an active fraction from rhizomes of Picrorhiza kurrooa.
The hepatoprotective activity of picroliv, the irridoid glycoside mixture from Picrorhiza kurrooa, was determined in adult male albino rats and seems likely due to an alteration in the biotransformation of the toxic substances resulting in decreased formation of reactive metabolites. Expand
Andrographolide protects rat hepatocytes against paracetamol-induced damage.
Andrographolide, the active constituent isolated from the plant Andrographis paniculata, showed a significant dose dependent protective activity against paracetamol-induced toxicity on ex vivo preparation of isolated rat hepatocytes and was found to be more potent than silymarin, a standard hepatoprotective agent. Expand
Picroliv affords protection against thioacetamide-induced hepatic damage in rats.
Picroliv, a standardised glycoside fraction of Picrorhiza kurroa, in doses of 12.5 and 25 mg/kg prevented most of the biochemical changes induced by thioacetamide in liver and serum and was comparable with that of silymarin, a known hepatoprotective agent obtained from seeds of Silybum marianum. Expand
Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats.
Oral administration of Picroliv (12 mg/kg/day for 7 days), a standardised iridoid glycoside fraction of Picrorhiza kurroa, significantly prevented the biochemical changes in liver and serum of galactosamine-toxicated rats. Expand
Comparative behavioural effects of typical and atypical antipsychotic drugs in rhesus monkey.
Risperidone had advantages over the other antipsychotic drugs used in this study because it did not produce salivation, had minimal extrapyramidal effects and caused less sedation, and could be a useful predictive tool in the preclinical development of new antipsychotics. Expand
Hepatoprotective activity of kutkin--the iridoid glycoside mixture of Picrorhiza kurrooa.