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ceftobiprole medocaril

Known as: ceftobiprole medocaril sodium 
A water-soluble prodrug of ceftobiprole, a pyrrolidinone cephalosporin antibiotic, with bactericidal activity. Ceftobiprole binds to and inactivates… 
National Institutes of Health

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Broader (2)

Anti-Bacterial AgentsCephalosporins

Narrower (1)

BAL5788
ceftobiprole medocaril free acid

Papers overview

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2016
2016
A pooled analysis of clinical cure and mortality with ceftobiprole medocaril versus comparators in staphylococcal bacteraemia in complicated skin infections, and community- and hospital-acquired…
2015
2015
Clinical cure and mortality outcomes with ceftobiprole medocaril versus ceftazidime plus linezolid in patients with early versus late-onset hospital-acquired pneumonia.
Objectives: Ceftobiprole, the active moiety of the prodrug ceftobiprole medocaril, is a novel cephalosporin for intravenous use… 
2014
2014
Antimicrobial Activity of Ceftobiprole Tested against Staphylococci and Streptococci from European Countries and Israel (2013)
0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (0.4) 51 (11.1) 272 (67.8) 152 (99.6) 2 (100.0) -- -- 1 2 Coagulase-negative… 
Review
2013
Review
2013
Pharmacokinetic and pharmacodynamics evaluation of ceftobiprole medocaril for the treatment of hospital-acquired pneumonia
Introduction: Ceftobiprole is a cephalosporin with activity against methicillin-resistant Staphylococcus aureus… 
2013
2013
Ceftobiprole medocaril is an effective treatment against methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis in a rat model
Methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis after median sternotomy is a major complication of cardiac… 
2012
2012
Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs: a case study example with the prodrug ceftobiprole medocaril.
An approach was developed that uses enzyme inhibitors to support the assessment of the pathways that are responsible for the… 
2010
2010
Resistance and the management of complicated skin and skin structure infections: the role of ceftobiprole
Antimicrobial resistant bacteria are an increasing concern due to the resulting increase in morbidity, mortality, and health-care… 
2009
2009
A Randomized, Double-Blind Trial Comparing Ceftobiprole Medocaril with Vancomycin plus Ceftazidime for the Treatment of Patients with Complicated Skin and Skin-Structure Infections
2008
2008
Monographs: Ceftobiprole medocaril: a new generation beta-lactam.
2005
2005
Ceftobiprole/ceftobiprole : Medocaril cephalosporin antibiotic
Over the past decade, resistance to antimicrobials has increased dramatically and is limiting the therapeutic options for the… 
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