Ceftobiprole medocaril is an effective treatment against methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis in a rat model

@article{Barnea2013CeftobiproleMI,
  title={Ceftobiprole medocaril is an effective treatment against methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis in a rat model},
  author={Yoav Barnea and Shiri Navon-Venezia and Boris Kuzmenko and Natalie Artzi and Yehuda Carmeli},
  journal={European Journal of Clinical Microbiology & Infectious Diseases},
  year={2013},
  volume={33},
  pages={325-329}
}
Methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis after median sternotomy is a major complication of cardiac surgery with significant morbidity and mortality rates. We evaluated the efficacy of ceftobiprole medocaril in a new rat model of mediastinitis and compared it to vancomycin. The model was induced in 92 rats. Infection was induced immediately after median sternotomy by the injection of MRSA (strain 3020, 1 × 107 cfu/rat) into the sternal bone. After 24 h, rats (groups of 6… CONTINUE READING
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