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Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
BACKGROUND Progressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease,Expand
Intensive insulin therapy and pentastarch resuscitation in severe sepsis.
BACKGROUND The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking toExpand
Clinical and economic burden of community-acquired pneumonia among adults in Europe
It is difficult to determine the impact of community-acquired pneumonia (CAP) in Europe, because precise data are scarce. Mortality attributable to CAP varies widely between European countries andExpand
Epidemiology of sepsis in Germany: results from a national prospective multicenter study
ObjectiveTo determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size.DesignProspective, observational, cross-sectional 1-dayExpand
European Respiratory Society guidelines for the management of adult bronchiectasis
Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent exacerbations in many patients. There have been no previous international guidelines. The EuropeanExpand
Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial.
BACKGROUND Evidence is weak for the ability of long-term non-invasive positive pressure ventilation (NPPV) to improve survival in patients with stable hypercapnic chronic obstructive pulmonaryExpand
International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia
The most recent European guidelines and task force reports on hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) were published almost 10 years ago. Since then, furtherExpand
New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality
Background: The database of the German programme for quality in healthcare including data of every hospitalised patient with community-acquired pneumonia (CAP) during a 2-year period (n = 388 406Expand
Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth
Removal of apoptotic cells by neighboring viable cells or professional phagocytes is essential for the maintenance of tissue homeostastis. Here we show that the phagocytosis of apoptotic Jurkat TExpand
Extracorporeal membrane oxygenation in awake patients as bridge to lung transplantation.
RATIONALE The use of extracorporeal membrane oxygenation (ECMO) in patients who are awake and spontaneously breathing may represent a novel bridging strategy toward lung transplantation (LuTx). Expand