caspase-10

Known as: Caspase 10, Caspase 10 [Chemical/Ingredient] 
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
We performed a loss-of-function RNA interference screen to define therapeutic targets in multiple myeloma, a genetically diverse… (More)
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Highly Cited
2011
Highly Cited
2011
The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes the… (More)
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Highly Cited
2008
Highly Cited
2008
Apoptosis, a fundamental process essential for normal tissue homeostasis and development, is closely associated with the… (More)
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Highly Cited
2004
Highly Cited
2004
Taxol (paclitaxel) is known to inhibit cell growth and trigger significant apoptosis in various cancer cells. Although taxol… (More)
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Highly Cited
2002
Highly Cited
2002
Apoptosis is a form of programmed cell death that is controlled by aspartate-specific cysteine proteases called caspases. In the… (More)
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Review
2002
Review
2002
Death receptor- or mitochondrion-dependent apoptosis is initiated by the recruitment and activation of apical caspases in the… (More)
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Highly Cited
2002
Highly Cited
2002
Methylation of the promoter regions of CpG-rich sites in genes is the major mechanism for the silencing of many genes in tumors… (More)
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Highly Cited
2001
Highly Cited
2001
A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not… (More)
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Highly Cited
1999
Highly Cited
1999
Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report… (More)
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Highly Cited
1997
Highly Cited
1997
We have identified and characterized CLARP, a caspase-like apoptosis-regulatory protein. Sequence analysis revealed that human… (More)
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