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caspase-10

Known as: Caspase 10, Caspase 10 [Chemical/Ingredient] 
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of… 
National Institutes of Health

Related topics

Related topics

23 relations
Autoimmune Lymphoproliferative SyndromeCASP10 geneCASP10 wt AlleleCASP2 protein, human

Narrower (2)

CASP10 protein, humancaspase-10b

Broader (1)

Cysteine Endopeptidases

Papers overview

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Highly Cited
2007
Highly Cited
2007
Caspase-3 status is a determinant of the differential responses to genistein between MDA-MB-231 and MCF-7 breast cancer cells.
Highly Cited
2006
Highly Cited
2006
Unique and overlapping substrate specificities of caspase-8 and caspase-10
Although caspase-8 has an established role as an initiator of death receptor-mediated apoptosis, the function of its closest… 
Highly Cited
2005
Highly Cited
2005
Caspase-10 Triggers Bid Cleavage and Caspase Cascade Activation in FasL-induced Apoptosis*
In contrast to caspase-8, controversy exists as to the ability of caspase-10 to mediate apoptosis in response to FasL. Herein, we… 
Highly Cited
2003
Highly Cited
2003
Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation
Highly Cited
2002
Highly Cited
2002
X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial…
The resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis could be… 
Highly Cited
2002
Highly Cited
2002
Inactivating mutations of the caspase-10 gene in gastric cancer
We have analysed the genetic alteration of the entire coding region and all splice sites of caspase-8 and -10 genes in 99 gastric… 
Highly Cited
2001
Highly Cited
2001
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
Disruption of apoptotic pathways may be involved in tumor formation, regression, and treatment resistance of neuroblastoma (NB… 
Highly Cited
2000
Highly Cited
2000
Activation of the NF-κB pathway by Caspase 8 and its homologs
Caspase 8 is the most proximal caspase in the caspase cascade and has been known for its role in the mediation of cell death by… 
Highly Cited
1999
Highly Cited
1999
Molecular Cloning and Characterization of Two Novel Pro-apoptotic Isoforms of Caspase-10*
Caspase-10/a (Mch4) and caspase-10/b (FLICE2) are related death effector domain-containing cysteine aspartases presumed to be at… 
Highly Cited
1997
Highly Cited
1997
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.
We have identified and characterized CLARP, a caspase-like apoptosis-regulatory protein. Sequence analysis revealed that human… 
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