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caspase-10

Known as: Caspase 10, Caspase 10 [Chemical/Ingredient] 
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of… 
National Institutes of Health

Related topics

Related topics

23 relations
Autoimmune Lymphoproliferative SyndromeCASP10 geneCASP10 wt AlleleCASP2 protein, human

Narrower (2)

CASP10 protein, humancaspase-10b

Broader (1)

Cysteine Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Nickel chloride-induced apoptosis via mitochondria- and Fas-mediated caspase-dependent pathways in broiler chickens
Ni, a metal with industrial and commercial uses, poses a serious hazard to human and animal health. In the present study, we used… 
2011
2011
Apoptosis induced by avian H5N1 virus in human monocyte-derived macrophages involves TRAIL-inducing caspase-10 activation
Avian influenza virus H5N1 is a potentially fatal disease not only in birds, but also in humans. The virus is able to induce… 
2010
2010
Caspase-10-Dependent Cell Death in Fas/CD95 Signalling Is Not Abrogated by Caspase Inhibitor zVAD-fmk
Background Upon CD95/Fas ligation, the initiator caspase-8 is known to activate effector caspases leading to apoptosis. In the… 
2010
2010
Somatic ALPS: a FAScinating condition.
Consider a patient who presents with lymphadenopathy, splenomegaly, and pancytopenia and is discovered to have an atypical… 
2006
2006
The initiator caspase, caspase‐10β, and the BH‐3‐only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro‐apoptotic activities in the extrinsic and intrinsic pathways
Two major apoptotic signaling pathways have been defined in mammals, the extrinsic pathway, initiated by ligation of death… 
Highly Cited
2005
Highly Cited
2005
HIV‐1 Tat protein concomitantly down‐regulates apical caspase‐10 and up‐regulates c‐FLIP in lymphoid T cells: A potential molecular mechanism to escape TRAIL cytotoxicity
In this study, we showed the existence of a positive correlation between the amount of human immunodeficiency virus‐type 1 (HIV‐1… 
2004
2004
Caspase-mediated Cleavage of Insulin Receptor Substrate*
Apoptosis is an important mechanism for maintaining tissue homeostasis. The efficient induction and execution of apoptosis are… 
2003
2003
LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level.
The deoxyspergualin derivative LF 15-0195 has demonstrated some efficacy in animal models of autoimmune and graft-versus-host… 
Highly Cited
1999
Highly Cited
1999
Molecular Cloning and Characterization of Two Novel Pro-apoptotic Isoforms of Caspase-10*
Caspase-10/a (Mch4) and caspase-10/b (FLICE2) are related death effector domain-containing cysteine aspartases presumed to be at… 
Highly Cited
1999
Highly Cited
1999
Activation of the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway by Overexpression of Caspase-8 and Its Homologs*
Caspase-8 is the most proximal caspase in the caspase cascade and possesses a prodomain consisting of two homologous death… 
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