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caspase-10

Known as: Caspase 10, Caspase 10 [Chemical/Ingredient] 
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of… 
National Institutes of Health

Related topics

Related topics

23 relations
Autoimmune Lymphoproliferative SyndromeCASP10 geneCASP10 wt AlleleCASP2 protein, human

Narrower (2)

CASP10 protein, humancaspase-10b

Broader (1)

Cysteine Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Autosis: a new addition to the cell death tower of babel
Autophagy is a cellular recycling and stress response that degrades organelles and long-lived proteins and serves to protect… 
2006
2006
Mutation of the Myxoma virus SERP2 P1-site to prevent proteinase inhibition causes apoptosis in cultured RK-13 cells and attenuates disease in rabbits, but mutation to alter specificity causes…
Highly Cited
2005
Highly Cited
2005
HIV‐1 Tat protein concomitantly down‐regulates apical caspase‐10 and up‐regulates c‐FLIP in lymphoid T cells: A potential molecular mechanism to escape TRAIL cytotoxicity
In this study, we showed the existence of a positive correlation between the amount of human immunodeficiency virus‐type 1 (HIV‐1… 
Highly Cited
2003
Highly Cited
2003
Caspase activation during phorbol ester-induced apoptosis requires ROCK-dependent myosin-mediated contraction
Treatment of cells with phorbol ester, phorbol-12-myristate-13-acetate (PMA), triggers differentiation or apoptosis, depending on… 
2003
2003
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.
NF-kappaB regulates the expression of various genes involved in cell growth and differentiation, immune response and inhibition… 
Highly Cited
2001
Highly Cited
2001
Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma
We previously reported a high incidence of loss of heterozygosity (LOH) on chromosome 2q33 in neuroblastoma (NB), observed in… 
Highly Cited
2001
Highly Cited
2001
Fas (CD95) May Mediate Delayed Cell Death in Hippocampal CA1 Sector after Global Cerebral Ischemia
Cell death–regulatory genes like caspases and bcl-2 family genes are involved in delayed cell death in the CA1 sector of… 
Highly Cited
1999
Highly Cited
1999
Molecular Cloning and Characterization of Two Novel Pro-apoptotic Isoforms of Caspase-10*
Caspase-10/a (Mch4) and caspase-10/b (FLICE2) are related death effector domain-containing cysteine aspartases presumed to be at… 
Highly Cited
1999
Highly Cited
1999
Activation of the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway by Overexpression of Caspase-8 and Its Homologs*
Caspase-8 is the most proximal caspase in the caspase cascade and possesses a prodomain consisting of two homologous death… 
Highly Cited
1997
Highly Cited
1997
Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis
We report that the serine protease granzyme B (GrB), which is crucial for granule-mediated cell killing, initiates apoptosis in… 
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