FAQ

Autoimmune Lymphoproliferative Syndrome

Known as: Canale-Smith Syndromes, Canale Smith Syndrome, Syndrome, Canale-Smith 
Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS… (More)

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Topic mentions per year

1983-2018
0204019832018

Related topics

Related topics

31 relations
AnemiaAtypical lymphocyteAutoimmune DiseasesAutoimmune hemolytic anemia
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Narrower (2)

Autoimmune Lymphoproliferative Syndrome Type 2BDianzani autoimmune lymphoproliferative syndrome

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Autoimmune Lymphoproliferative Syndrome
Anemia
Immune system
Autoimmune Diseases
Hodgkin Disease
Thrombocytopenia

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
NRAS mutation causes a human autoimmune lymphoproliferative syndrome.
The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization… (More)
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2006
2006
Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS).
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated… (More)
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Highly Cited
2004
Highly Cited
2004
Autoimmune lymphoproliferative syndrome with somatic Fas mutations.
BACKGROUND Impaired Fas-induced apoptosis of lymphocytes in vitro is a principal feature of the autoimmune lymphoproliferative… (More)
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Highly Cited
2001
Highly Cited
2001
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.
Lymphomas were studied in kindreds with autoimmune lymphoproliferative syndrome (ALPS; Canale-Smith syndrome), a disorder of… (More)
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Highly Cited
1999
Highly Cited
1999
Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II
Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report… (More)
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Highly Cited
1999
Highly Cited
1999
Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance.
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance. Most patients… (More)
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1998
1998
Pathological findings in human autoimmune lymphoproliferative syndrome.
The defects in lymphocyte apoptosis that underlie the autoimmune lymphoproliferative syndrome (ALPS) are usually attributable to… (More)
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Highly Cited
1997
Highly Cited
1997
Clinical, Immunologic, and Genetic Features of an Autoimmune Lymphoproliferative Syndrome Associated With Abnormal Lymphocyte Apoptosis
Programmed cell death (apoptosis) of activated lymphoan unusual population of CD4CD8 T cells that express the a/b T-cell receptor… (More)
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Highly Cited
1996
Highly Cited
1996
Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.
The pathogenesis of systemic lupus erythematosus (SLE) is multifactorial and multigenetic. The apoptosis genes, fas and fas… (More)
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Highly Cited
1995
Highly Cited
1995
Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
Five unrelated children are described with a rare autoimmune lymphoproliferative syndrome (ALPS) characterized by massive… (More)
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