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Autoimmune Lymphoproliferative Syndrome

Known as: Canale-Smith Syndromes, Canale Smith Syndrome, Syndrome, Canale-Smith 
Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS… Expand
National Institutes of Health

Related topics

Related topics

32 relations
AnemiaAtypical lymphocyteAutoimmune DiseasesAutoimmune hemolytic anemia
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Narrower (3)

Autoimmune Lymphoproliferative Syndrome Type 2BAutoimmune Lymphoproliferative Syndrome, Type IIADianzani autoimmune lymphoproliferative syndrome

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
How I treat autoimmune lymphoproliferative syndrome.
Autoimmune lymphoproliferative syndrome (ALPS) represents a failure of apoptotic mechanisms to maintain lymphocyte homeostasis… Expand
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Highly Cited
2010
Highly Cited
2010
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop.
Lymphadenopathy in children for which no infectious or malignant cause can be ascertained constitutes a challenging diagnostic… Expand
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Highly Cited
2007
Highly Cited
2007
NRAS mutation causes a human autoimmune lymphoproliferative syndrome
The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization… Expand
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Highly Cited
2005
Highly Cited
2005
Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS).
Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of disrupted lymphocyte homeostasis. Clinical manifestations of… Expand
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Highly Cited
2004
Highly Cited
2004
Autoimmune lymphoproliferative syndrome with somatic Fas mutations.
BACKGROUND Impaired Fas-induced apoptosis of lymphocytes in vitro is a principal feature of the autoimmune lymphoproliferative… Expand
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Highly Cited
2001
Highly Cited
2001
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.
Lymphomas were studied in kindreds with autoimmune lymphoproliferative syndrome (ALPS; Canale-Smith syndrome), a disorder of… Expand
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Highly Cited
1999
Highly Cited
1999
Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II
Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report… Expand
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Review
1999
Review
1999
Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.
Apoptosis of mature T lymphocytes preserves peripheral homeostasis and tolerance by countering the profound changes in the number… Expand
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Highly Cited
1998
Highly Cited
1998
CLIMATE CHANGE AND ITS IMPACTS ON GLACIERS AND PERMAFROST IN THE ALPS
Climate change in the European Alps during the 20th century has been characterized by increases in minimum temperatures of about… Expand
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Highly Cited
1995
Highly Cited
1995
Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
Five unrelated children are described with a rare autoimmune lymphoproliferative syndrome (ALPS) characterized by massive… Expand
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