Autoimmune Lymphoproliferative Syndrome

Known as: Canale-Smith Syndromes, Canale Smith Syndrome, Syndrome, Canale-Smith 
Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS… (More)

Topic mentions per year

Topic mentions per year

1983-2018
0204019832018

Papers overview

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Highly Cited
2007
Highly Cited
2007
The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization… (More)
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2006
2006
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Impaired Fas-induced apoptosis of lymphocytes in vitro is a principal feature of the autoimmune lymphoproliferative… (More)
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Highly Cited
2001
Highly Cited
2001
Lymphomas were studied in kindreds with autoimmune lymphoproliferative syndrome (ALPS; Canale-Smith syndrome), a disorder of… (More)
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Highly Cited
1999
Highly Cited
1999
Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report… (More)
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Highly Cited
1999
Highly Cited
1999
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance. Most patients… (More)
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1998
1998
The defects in lymphocyte apoptosis that underlie the autoimmune lymphoproliferative syndrome (ALPS) are usually attributable to… (More)
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Highly Cited
1997
Highly Cited
1997
Programmed cell death (apoptosis) of activated lymphoan unusual population of CD4CD8 T cells that express the a/b T-cell receptor… (More)
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Highly Cited
1996
Highly Cited
1996
The pathogenesis of systemic lupus erythematosus (SLE) is multifactorial and multigenetic. The apoptosis genes, fas and fas… (More)
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Highly Cited
1995
Highly Cited
1995
Five unrelated children are described with a rare autoimmune lymphoproliferative syndrome (ALPS) characterized by massive… (More)
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