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candoxatrilat

Known as: 4-((2-carboxy-3-(2-methoxyethoxy)propyl)-1-cyclopentanecarbonylamino)-1-cyclohexanecarboxylic acid, Cyclohexanecarboxylic acid, 4-(((1-(2-carboxy-3-(2-methoxyethoxy)propyl)cyclopentyl)carbonyl)amino)-, cis-(+-)- 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Cyclohexanecarboxylic AcidsProtease Inhibitors

Narrower (2)

UK 69578UK 73967

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Restorative Effect of Atrial Natriuretic Peptide or Chronic Neutral Endopeptidase Inhibition on Blunted Cardiopulmonary Vagal Reflexes in Aged Rats
Arterial baroreflex function diminishes with age, but whether cardiopulmonary vagal reflexes are similarly altered with… 
2007
2007
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.
2006
2006
Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis.
Neutral endopeptidase degrades atrial natriuretic peptide (ANP) and bradykinin and may generate endothelin-1 from big-endothelin… 
1997
1997
Neutral endopeptidase regulates C-type natriuretic peptide metabolism but does not potentiate its bioactivity in vivo.
C-type natriuretic peptide (CNP) is a newly described 22-amino acid peptide of endothelial and renal cell origin with selective… 
1997
1997
Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure.
Atrial natriuretic factor (ANF) has natriuretic, renin-suppressing and chronic hypotensive actions that may be utilized by… 
1997
1997
Acute reversal of cyclosporine nephrotoxicity by neutral endopeptidase inhibition in stable renal transplant recipients.
BACKGROUND Atrial natriuretic peptide and cyclosporine have opposing effects on renal hemodynamics and excretory function… 
1995
1995
Natriuretic response to neutral endopeptidase inhibition is blunted by enalapril in healthy men.
We studied six healthy male subjects in a randomized, placebo-controlled, single-blind fashion to determine the comparative… 
1994
1994
Inhibition of thermolysin and neutral endopeptidase 24.11 by a novel glutaramide derivative: X-ray structure determination of the thermolysin-inhibitor complex.
Determination of the X-ray structure of thermolysin-inhibitor complexes has proven useful in aiding our understanding of the mode… 
1993
1993
Renal effects of neutral endopeptidase inhibition in euvolemic and hypervolemic rats.
1992
1992
Increased circulating atrial natriuretic factor concentrations in patients with chronic heart failure after inhibition of neutral endopeptidase: effects on diastolic function
Objective—±Candoxatrilat was used to raise atrial natriuretic factor (ANF) concentrations in patients with heart failure, and the… 
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