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candoxatrilat

Known as: 4-((2-carboxy-3-(2-methoxyethoxy)propyl)-1-cyclopentanecarbonylamino)-1-cyclohexanecarboxylic acid, Cyclohexanecarboxylic acid, 4-(((1-(2-carboxy-3-(2-methoxyethoxy)propyl)cyclopentyl)carbonyl)amino)-, cis-(+-)- 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Cyclohexanecarboxylic AcidsProtease Inhibitors

Narrower (2)

UK 69578UK 73967

Papers overview

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2007
2007
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.
2006
2006
Overexpression of kidney neutral endopeptidase (EC 3.4.24.11) and renal function in experimental cirrhosis.
Neutral endopeptidase degrades atrial natriuretic peptide (ANP) and bradykinin and may generate endothelin-1 from big-endothelin… 
Highly Cited
1999
Highly Cited
1999
Renal response to acute neutral endopeptidase inhibition in mild and severe experimental heart failure.
BACKGROUND Neutral endopeptidase 24.11 (NEP) is a metalloprotease that is localized in the greatest abundance in the kidney and… 
1997
1997
Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril.
1. Candoxatrilat, an active neutral endopeptidase inhibitor, was released rapidly from the inactive prodrug candoxatril in vivo… 
1997
1997
Neutral endopeptidase regulates C-type natriuretic peptide metabolism but does not potentiate its bioactivity in vivo.
C-type natriuretic peptide (CNP) is a newly described 22-amino acid peptide of endothelial and renal cell origin with selective… 
1997
1997
Enhanced natriuretic response to neutral endopeptidase inhibition in patients with moderate chronic renal failure.
Atrial natriuretic factor (ANF) has natriuretic, renin-suppressing and chronic hypotensive actions that may be utilized by… 
1995
1995
Natriuretic response to neutral endopeptidase inhibition is blunted by enalapril in healthy men.
We studied six healthy male subjects in a randomized, placebo-controlled, single-blind fashion to determine the comparative… 
1995
1995
Renal response to candoxatrilat in patients with heart failure.
1994
1994
Inhibition of thermolysin and neutral endopeptidase 24.11 by a novel glutaramide derivative: X-ray structure determination of the thermolysin-inhibitor complex.
Determination of the X-ray structure of thermolysin-inhibitor complexes has proven useful in aiding our understanding of the mode… 
1993
1993
Renal effects of neutral endopeptidase inhibition in euvolemic and hypervolemic rats.
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