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calphostin C

Known as: Carbonic acid, 2-(12-(2-(benzoyloxy)propyl)-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl)-1-methylethyl 4-hydroxyphenyl ester 
 
National Institutes of Health

Papers overview

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2000
2000
Calphostin C-mediated apoptosis in glioma cells was reported previously to be associated with down-regulation of Bcl-2 and Bcl-xL… Expand
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Highly Cited
1999
Highly Cited
1999
Apoptosis was induced in human glioma cell lines by exposure to 100 nm calphostin C, a specific inhibitor of protein kinase C… Expand
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Highly Cited
1999
Highly Cited
1999
Wortmannin selectively impairs insulin-stimulated glucose transport in skeletal muscle. To search for an inhibitor specific for… Expand
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Highly Cited
1998
Highly Cited
1998
Recent studies have demonstrated that the naturally occurring perylenequinone antibiotic calphostin C is a potent inhibitor of… Expand
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Highly Cited
1995
Highly Cited
1995
Protein kinase C (PKC) undergoes specific inactivation by nanomolar concentrations of calphostin C. Both PKC‐α (a Ca2+‐dependent… Expand
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Highly Cited
1995
Highly Cited
1995
Calphostin C acts at the regulatory domain as a highly selective inhibitor of protein kinase C (PKC), and staurosporine acts at… Expand
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Highly Cited
1995
Highly Cited
1995
  • Y. Li, R. Kloner
  • The American journal of physiology
  • 1995
  • Corpus ID: 22744689
Protein kinase C (PKC) has been implicated in the cardioprotective effects of ischemic preconditioning in rabbits, but whether it… Expand
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Highly Cited
1994
Highly Cited
1994
OBJECTIVE The aim was to determine if isolated rabbit cardiomyocytes could be preconditioned. METHODS Cardiomyocytes isolated… Expand
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Highly Cited
1992
Highly Cited
1992
Isolated protein kinase C (PKC) was irreversibly inactivated by a brief (min) incubation with calphostin C in the presence of… Expand
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Highly Cited
1989
Highly Cited
1989
Calphostin C (UCN-1028C), a newly isolated compound from Cladosporium cladosporioides, is a potent and specific inhibitor of… Expand
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