PKC inhibition is involved in trichosanthin-induced apoptosis in human chronic myeloid leukemia cell line K562.

@article{Li2007PKCII,
  title={PKC inhibition is involved in trichosanthin-induced apoptosis in human chronic myeloid leukemia cell line K562.},
  author={J. Li and Xuechun Xia and Huiling Nie and Mark A. Smith and Xiongwei Zhu},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1770 1},
  pages={
          63-70
        }
}
Trichosanthin (TCS), a type I ribosome-inactivating protein, induces cell death in various cell types including several tumor cell lines. However, the mechanism remains largely uncharacterized. In this study, we investigated the possible mechanism underlying its cytotoxicity by using human chronic myeloid leukemia cell line K562. We found that TCS induced apoptosis in K562 cells in a time- and concentration-dependent manner and can be blocked by caspase-3 inhibitors. Interestingly, TCS… Expand
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