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cGMP-Dependent Protein Kinase Ialpha

Known as: PKGIalpha, cGK-Ialpha, cGMP Dependent Protein Kinase Ialpha 
 
National Institutes of Health

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Cyclic GMP-Dependent Protein Kinase Type I

Papers overview

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2010
2010
Protein kinase G type-Iα phosphorylates the apoptosis-regulating protein Bad at serine 155 and protects against apoptosis in N1E-115 cells
Previous studies from our laboratory have shown that the cGMP/protein kinase G (PKG) signaling pathway plays an essential role in… Expand
2010
2010
Aromatic l‐amino acid decarboxylase phosphorylation and activation by PKGIαin vitro
J. Neurochem. (2010) 114, 542–552. 
Highly Cited
2009
Highly Cited
2009
Transnitrosylating Nitric Oxide Species Directly Activate Type I Protein Kinase A, Providing a Novel Adenylate Cyclase-independent Cross-talk to β-Adrenergic-like Signaling*
The transnitrosylating nitric oxide (NO) donor nitrocysteine (CysNO) induced a disulfide bond between the two regulatory RI… Expand
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2009
2009
Contribution of PIP-5 kinase Ialpha to raft-based FcgammaRIIA signaling.
Receptor FcgammaIIA (FcgammaRIIA) associates with plasma membrane rafts upon activation to trigger signaling cascades leading to… Expand
Highly Cited
2008
Highly Cited
2008
High blood pressure arising from a defect in vascular function
Hypertension, a major cardiovascular risk factor and cause of mortality worldwide, is thought to arise from primary renal… Expand
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Highly Cited
2007
Highly Cited
2007
Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation
Changes in the concentration of oxidants in cells can regulate biochemical signaling mechanisms that control cell function. We… Expand
Highly Cited
2006
Highly Cited
2006
Cyclic GMP-dependent Protein Kinase Iα Attenuates Necrosis and Apoptosis Following Ischemia/Reoxygenation in Adult Cardiomyocyte*
Cyclic GMP-dependent protein kinases protein kinase G (PKG) Iα and PKGIβ are major mediators of cGMP signaling in the… Expand
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2006
2006
Cyclic GMP-dependent Protein Kinase Iα Inhibits Thrombin Receptor-mediated Calcium Mobilization in Vascular Smooth Muscle Cells*
Vascular smooth muscle contractile state is regulated by intracellular calcium levels. Nitric oxide causes vascular relaxation by… Expand
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2006
2006
Isolated Regulatory Domains of cGMP-dependent Protein Kinase Iα and Iβ Retain Dimerization and Native cGMP-binding Properties and Undergo Isoform-specific Conformational Changes*
Molecular mechanisms that provide for cGMP activation of cGMP-dependent protein kinase (PKG) are unknown. PKGs are dimeric; each… Expand
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2004
2004
Formin Homology Domain Protein (FHOD1) Is a Cyclic GMP-dependent Protein Kinase I-binding Protein and Substrate in Vascular Smooth Muscle Cells*
Cyclic GMP-dependent protein kinase I (PKGI) mediates vascular relaxation by nitric oxide and related nitrovasodilators and… Expand
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