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The protective effects of estrogen on the cardiovascular system.
The incidence of cardiovascular disease differs significantly between men and women, in part because of differences in risk factors and hormones.1 The incidence of atherosclerotic diseases is low inExpand
Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen.
Estrogen is an important vasoprotective molecule that causes the rapid dilation of blood vessels by activating endothelial nitric oxide synthase (eNOS) through an unknown mechanism. In studies ofExpand
High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase
Atherosclerosis is the primary cause of cardiovascular disease, and the risk for atherosclerosis is inversely proportional to circulating levels of high-density lipoprotein (HDL) cholesterol.Expand
Protective effects of estrogen on the cardiovascular system.
  • M. Mendelsohn
  • Medicine
  • The American journal of cardiology
  • 10 June 1999
Estrogen has direct and indirect effects on the cardiovascular system that are mediated by the estrogen receptors ER-alpha and ER-beta. The direct effects of estrogen occur through rapid nongenomicExpand
Molecular and Cellular Basis of Cardiovascular Gender Differences
Cardiovascular diseases (CVDs), the major cause of morbidity and mortality for both men and women, occur uncommonly in premenopausal women, but their incidence rises sharply after the menopausalExpand
Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha.
Contraction and relaxation of smooth muscle are regulated by myosin light-chain kinase and myosin phosphatase through phosphorylation and dephosphorylation of myosin light chains. Cyclic guanosineExpand
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure
Nitric oxide (NO) inhibits vascular contraction by activating cGMP-dependent protein kinase I-α (PKGI-α), which causes dephosphorylation of myosin light chain (MLC) and vascular smooth muscleExpand
Evidence-based guidelines for cardiovascular disease prevention in women.
Expert Panel/Writing Group* Lori Mosca, MD, PhD (Chair); Lawrence J. Appel, MD; Emelia J. Benjamin, MD; Kathy Berra, MSN, ANP; Nisha Chandra-Strobos, MD; Rosalind P. Fabunmi, PhD; Deborah Grady, MD,Expand
Genomic and nongenomic effects of estrogen in the vasculature.
  • M. Mendelsohn
  • Medicine
  • The American journal of cardiology
  • 3 July 2002
Estrogen has both rapid vasodilatory effects and longer-term effects on the vasculature. The longer-term effects of estrogen are produced, at least in part, by changes in vascular cell gene andExpand
Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women
Significant advances in our knowledge about interventions to prevent cardiovascular disease (CVD) have occurred since publication of the first female-specific recommendations for preventiveExpand
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