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bryostatin 1

Known as: Bryostatin-1, Bryostatin I, BRYO 
A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (4)

Antineoplastic AgentsBryostatinsImmunologic Adjuvantsanimal extract
Inhibition of Cell ProliferationNCIt Antineoplastic Agent TerminologyPositive Regulation of ApoptosisPositive Regulation of Cell Differentiation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Panning for chemical gold: marine bacteria as a source of new therapeutics.
Highly Cited
2004
Highly Cited
2004
Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice.
Alzheimer's disease (AD) characteristically presents with early memory loss. Regulation of K(+) channels, calcium homeostasis… 
Review
1999
Review
1999
Microbial symbionts of marine invertebrates: opportunities for microbial biotechnology.
Marine invertebrates are sources of a diverse array of bioactive metabolites with great potential for development as drugs and… 
Highly Cited
1998
Highly Cited
1998
Identification of in Vivo Phosphorylation Sites Required for Protein Kinase D Activation*
Protein kinase D (PKD) is activated by phosphorylation in intact cells stimulated by phorbol esters, cell permeant… 
Highly Cited
1997
Highly Cited
1997
Bcl-2 Phosphorylation Required for Anti-apoptosis Function*
The protooncogene Bcl-2 functions as a suppressor of apoptosis in growth factor-dependent cells, but a post-receptor signaling… 
Highly Cited
1994
Highly Cited
1994
Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.
Highly Cited
1994
Highly Cited
1994
Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.
Highly Cited
1991
Highly Cited
1991
Selective translocation of beta II-protein kinase C to the nucleus of human promyelocytic (HL60) leukemia cells.
Highly Cited
1990
Highly Cited
1990
Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells.
Highly Cited
1985
Highly Cited
1985
Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor.
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