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bryostatin 1

Known as: Bryostatin-1, Bryostatin I, BRYO 
A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
The persistence of latently infected cells in patients under combinatory antiretroviral therapy (cART) is a major hurdle to HIV-1… Expand
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Highly Cited
2010
Highly Cited
2010
HIV's ability to establish long-lived latent infection is mainly due to transcriptional silencing in resting memory T lymphocytes… Expand
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Highly Cited
2010
Highly Cited
2010
David C. Pryde,* Deepak Dalvie, Qiyue Hu, Peter Jones, R. Scott Obach, ) and Thien-Duc Tran WorldWide Medicinal Chemistry, Pfizer… Expand
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Highly Cited
2008
Highly Cited
2008
Of the concepts used to improve the efficiency of organic syntheses, two have been especially effective: atom economy (the use of… Expand
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Highly Cited
2007
Highly Cited
2007
The bryostatins are protein kinase C modulators with unique structural features and potential anticancer and neurological… Expand
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Review
2001
Review
2001
Many pharmaceutical agents have been discovered by screening natural products from plants, animals, marine organisms and… Expand
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Highly Cited
1997
Highly Cited
1997
The protooncogene Bcl-2 functions as a suppressor of apoptosis in growth factor-dependent cells, but a post-receptor signaling… Expand
Highly Cited
1994
Highly Cited
1994
Bryostatin 1 and phorbol 12-myristate 13-acetate (PMA) are both potent activators of protein kinase C (PKC), although in many… Expand
Highly Cited
1991
Highly Cited
1991
A novel process was designed for the large-scale isolation of bryostatin 1 from the bryozoan Bugula neritina L. in order to… Expand
Highly Cited
1986
Highly Cited
1986
Phorbol esters bind to and activate a calcium phospholipid-dependent protein kinase (C kinase). Some researchers believe that… Expand