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bryostatin 1

Known as: Bryostatin-1, Bryostatin I, BRYO 
A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (4)

Antineoplastic AgentsBryostatinsImmunologic Adjuvantsanimal extract
Inhibition of Cell ProliferationNCIt Antineoplastic Agent TerminologyPositive Regulation of ApoptosisPositive Regulation of Cell Differentiation

Papers overview

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Highly Cited
2004
Highly Cited
2004
Structure of bryostatin 20: a symbiont-produced chemical defense for larvae of the host bryozoan, Bugula neritina.
Larvae of the marine bryozoan Bugula neritina are defended against potential predators by high concentrations of bryostatins… 
Highly Cited
1998
Highly Cited
1998
Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
PURPOSE To define, in a phase I study in relapsed non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL), the… 
Highly Cited
1994
Highly Cited
1994
Protein kinase C regulates keratinocyte transglutaminase (TGK) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calcium.
During the final stage of epidermal differentiation, activation of keratinocyte transglutaminase results in covalent crosslinking… 
Highly Cited
1992
Highly Cited
1992
Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.
The effects of the protein kinase C (PKC) activators, phorbol ester 12-O-tetradecanoyl-13-phorbol acetate (TPA) and the marine… 
Highly Cited
1991
Highly Cited
1991
Successful treatment of murine melanoma with bryostatin 1.
Bryostatins are a novel class of protein kinase C activators which were isolated from the marine bryozoan Bugula neritina and… 
Highly Cited
1989
Highly Cited
1989
Phorbol ester stimulates the hydrolysis of phosphatidylethanolamine in leukemic HL-60, NIH 3T3, and baby hamster kidney cells.
Highly Cited
1989
Highly Cited
1989
Varied differentiation responses of human leukemias to bryostatin 1.
Bryostatin 1, a macrocyclic lactone isolated from a marine bryozoan, has significant antineoplastic activity against the murine… 
Highly Cited
1988
Highly Cited
1988
Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C.
Highly Cited
1988
Highly Cited
1988
Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells.
Phorbol esters induce the human HL-60 promyelocytic cell line to differentiate along a monocytic pathway. This induction of… 
Highly Cited
1987
Highly Cited
1987
Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.
The bryostatins are macrocyclic lactones, extracted from the marine bryozoan Bugula neritina, and have been reported to be potent… 
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