bryostatin 1

Known as: Bryostatin-1, Bryostatin I, BRYO 
A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
The persistence of latently infected cells in patients under combinatory antiretroviral therapy (cART) is a major hurdle to HIV-1… (More)
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Highly Cited
2014
Highly Cited
2014
HIV-1 persists in a latent reservoir despite antiretroviral therapy (ART). This reservoir is the major barrier to HIV-1… (More)
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Highly Cited
2010
Highly Cited
2010
HIV's ability to establish long-lived latent infection is mainly due to transcriptional silencing in resting memory T lymphocytes… (More)
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Highly Cited
2007
Highly Cited
2007
The bryostatins are protein kinase C modulators with unique structural features and potential anticancer and neurological… (More)
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Review
2003
Review
2003
Modulation of PKC represents a novel approach to cancer therapy. Bryostatin-1 is a macrocyclic lactone derived from a marine… (More)
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Highly Cited
2001
Highly Cited
2001
The marine bryozoan, Bugula neritina, is the source of the bryostatins, a family of macrocyclic lactones with anticancer activity… (More)
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Highly Cited
1999
Highly Cited
1999
Modulating signal transduction pathways represents a promising approach for altering the biological behaviour of haemopoietic… (More)
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Highly Cited
1994
Highly Cited
1994
Using murine myeloid factor-dependent FDC-P1/ER cells, we demonstrate that the hematopoietic growth factors interleukin-3 and… (More)
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Highly Cited
1986
Highly Cited
1986
Phorbol esters bind to and activate a calcium phospholipid-dependent protein kinase (C kinase). Some researchers believe that… (More)
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