• Publications
  • Influence
Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development
The novel 11-kDa virucidal protein, named cyanovirin-N (CV-N), is isolated and sequenced from cultures of the cyanobacterium (blue-green alga) Nostoc ellipsosporum and is highly resistant to physicochemical denaturation, further enhancing its potential as an anti-HIV microbicide.
The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia and Clusia rosea
Abstract Extracts from species of the tropical plant genera Symphonia , Garcinia and Clusia (Guttiferae) have yielded a series of new polyisoprenylated benzophenone derivatives named guttiferones A–E
Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques.
It is indicated that CV-N gel as a topical microbicide can prevent rectal transmission of SHIV in macaques, and these studies encourage clinical evaluation ofCV-N as a Topical Microbicide to prevent sexual transmission of HIV in humans.
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
Calanolide A was active not only against the AZT-resistant G-9106 strain of HIV-1 but also against the pyridinone-resistant A17 strain, which was of particular interest since the A17 virus is highly resistant to previously known HIV- 1 specific, non-nucleoside RT inhibitors.
Solution structure of cyanovirin-N, a potent HIV-inactivating protein
The solution structure of cyanovirin-N, a potent 11,000 M r HIV-inactivating protein that binds with high affinity and specificity to the HIV surface envelope protein gp120, has been solved by
Papuamides A-D, HIV-inhibitory and cytotoxic depsipeptides from the sponges Theonella mirabilis and Theonella swinhoei, collected in Papua New Guinea
Papuamides A−D (1−4) are also the first marine-derived peptides reported to contain 3-hydroxyleucine and homoproline residues, and contain a previously undescribed 2,3-dihydroxy-2,6,8-trimethyldeca-(4Z,6E)-dienoic acid moiety N-linked to a terminal glycine residue.
Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping.
The crystal structure of cyanovirin-N (CV-N), a protein with potent antiviral activity, was solved at 1.5 A resolution by molecular replacement using as the search model the solution structure previously determined by NMR, with the exception of the unexpected phenomenon of domain swapping.
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.
Extracts of Homalanthus nutans, a plant used in Samoan herbal medicine, exhibited potent activity in an in vitro, tetrazolium-based assay which detects the inhibition of the cytopathic effects of
Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.
Bioassay-guided fractionation yielded two new guaiane sesquiterpenes, englerins A and B that showed 1000-fold selectivity against six of eight renal cancer cell lines with GI(50) values ranging from 1-87 nM.