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brodimoprim

Known as: 2,4-diamino-5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine 
National Institutes of Health

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5 relations

Broader (4)

Anti-Infective AgentsEnzyme InhibitorsFolic Acid AntagonistsTrimethoprim
analogs & derivatives

Papers overview

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2008
2008
Establishment of a liquid chromatographic/mass spectrometry method for quantification of tetrandrine in rat plasma and its application to pharmacokinetic study.
2008
2008
Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping…
2007
2007
Relationships between structural and thermal properties of anhydrous and solvated crystalline forms of brodimoprim.
The isolation and physicochemical characterization of four crystalline modifications of brodimoprim (5-[(4-bromo-3,5… 
1999
1999
1H/15N HSQC NMR studies of ligand carboxylate group interactions with arginine residues in complexes of brodimoprim analogues and Lactobacillus casei dihydrofolate reductase.
1H and 15N NMR studies have been undertaken on complexes of Lactobacillus casei dihydrofolate reductase (DHFR) formed with… 
1995
1995
Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase.
Two-dimensional (2D) double-quantum-filtered correlation spectroscopy (DQF-COSY), total correlation spectroscopy (TOCSY), nuclear… 
Review
1993
Review
1993
Comparative antibacterial spectrum of trimethoprim and brodimoprim.
Brodimoprim is a new 2,4-diaminobenzylpyrimidine that selectively inhibits bacterial and resistance plasmid dihydrofolate… 
1993
1993
Brodimoprim in acute respiratory tract infections.
Brodimoprim was studied in the treatment of acute respiratory tract infections in hospitalized, basically healthy, military… 
1991
1991
Brodimoprim versus amoxicillin in the treatment of acute sinusitis.
A new dihydrofolate inhibitor, brodimoprim, was compared with amoxicillin in the treatment of acute sinusitis in a general… 
1984
1984
A 1H NMR study of the interactions and conformations of rationally designed brodimoprim analogues in complexes with Lactobacillus casei dihydrofolate reductase.
A consideration of the detailed structural information available from X-ray crystallographic and NMR studies on complexes of… 
1984
1984
Properties of brodimoprim as an inhibitor of dihydrofolate reductases.
Based on both IC50 and Ki values, brodimoprim (BDP) was often found to be two- to threefold more effective than trimethoprim (TMP… 
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