bisnortilidine
National Institutes of Health
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The therapeutic activity of tilidine, an opioid analgesic, is mainly related to its active metabolite nortilidine. Nortilidine…
The opioid tilidine is a prodrug which is hepatically metabolized to active nortilidine and bisnortilidine. Due to the increasing…
The disposition of nortildine, the active metabolite of the synthetic opioid drug tilidine, was investigated in healthy…
The aim of the present study was to investigate the pharmacokinetics of tilidine and its metabolites during the dialysis…
Tilidine is a prodrug from which the active metabolite nortilidine is formed by demethylation. The pharmacokinetics of tilidine…
A gas liquid chromatographic method with nitrogen-phosphorus detection (GLC-NPD) is compared to a GLC-mass spectrometric…
A sensitive and specific GLC method is described to determine therapeutic levels of tilidine and its two main metabolites…
SummaryThe analgesic effect of tilidine in rats is completely antagonized by the narcotic antagonist naloxone. Radioreceptor…
We report a specific and sensitive method for determination of the individual optical isomers of nortilidine, a main metabolite…