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biricodar

Known as: N-(2-oxo-2-(3,4,5-trimethoxyphenyl)acety)piperidine-2-carboxylic acid 1,7-bis(3-pyridyl)-4-heptyl ester 
A pipecolinate derivative. Functioning as a modulator of P-glycoprotein (P-gp) and multidrug resistance protein (MRP-1), biricodar restores drug… 
National Institutes of Health

Related topics

Related topics

6 relations
Biricodar dicitrate

Narrower (3)

IncelVX 710VX 853

Broader (2)

PiperidinesPyridines

Papers overview

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2007
2007
Gateways to clinical trials.
[111In]-DOTA-cG250, [131I]-Metuximab injection, [177Lu]-DOTA-cG250; Anatumomab mafenatox, AP-12009; BIBW-2992, Biricodar… 
2003
2003
Safety and efficacy of the MDR inhibitor Incel (biricodar, VX-710) in combination with mitoxantrone and prednisone in hormone-refractory prostate cancer
PurposeVX-710 (biricodar, Incel) restores drug sensitivity to cells expressing P-glycoprotein (P-gp) and multidrug resistance… 
Review
2002
Review
2002
Biricodar. Vertex Pharmaceuticals.
Vertex is developing biricodar as a chemosensitizing agent designed to restore the effectiveness of chemotherapeutic agents in… 
Review
2002
Review
2002
99-Technetium Sestamibi Scanning to Predict the Efficacy of Estramustine Phosphate in Overcoming Paclitaxel Resistance in Patients With Advanced Breast Cancer
Abstract : This research investigates the ability of 99-Technetium Sestamibi Tc-99-SM) to serve as a non-invasive means of… 
Highly Cited
2001
Highly Cited
2001
Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin.
PURPOSE To evaluate the safety, tolerability, and pharmacokinetics of biricodar (VX-710), an inhibitor of P-glycoprotein (P-gp… 
1999
1999
A Phase II study of IncelTM (biricodar, VX-710) in combination with paclitaxel in women with advanced breast cancer refractory to paclitaxel
1999
1999
A Phase II study of the safety, pharmacokinetics and efficacy of IncelTM (biricodar, VX-710) in combination with mitoxantrone (M) and prednisone (P) in advanced hormone refractory prostate cancer…
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