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biotin binding

Known as: vitamin B7 binding, vitamin H binding 
Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Electrostatic polarization makes a substantial contribution to the free energy of avidin-biotin binding.
Avidin-biotin is one of the strongest protein-ligand binding systems, with broad applications in biomedical science. Here we… 
Highly Cited
2008
Highly Cited
2008
Monitoring of real-time streptavidin-biotin binding kinetics using droplet microfluidics.
Rapid kinetic measurements are important in understanding chemical interactions especially for biological molecules. Herein, we… 
Highly Cited
2006
Highly Cited
2006
A monovalent streptavidin with a single femtomolar biotin binding site
Streptavidin and avidin are used ubiquitously because of the remarkable affinity of their biotin binding, but they are tetramers… 
Highly Cited
2005
Highly Cited
2005
Engineering Soluble Monomeric Streptavidin with Reversible Biotin Binding Capability*
Monomeric streptavidin with reversible biotin binding capability has many potential applications. Because a complete biotin… 
Highly Cited
2004
Highly Cited
2004
Label-free biosensing by surface plasmon resonance of nanoparticles on glass: optimization of nanoparticle size.
The unique optical properties of noble metal nanoparticles have been used to design a label-free biosensor in a chip format. In… 
Highly Cited
2003
Highly Cited
2003
New Advance in Computational Chemistry:  Full Quantum Mechanical ab Initio Computation of Streptavidin-Biotin Interaction Energy.
Benchmark full quantum mechanical Hartree-Fock calculation has been carried out to compute interaction energies for the… 
2002
2002
A streptavidin-biotin binding system that minimizes blocking by endogenous biotin.
Pretargeted radioimmunotherapy specifically targets radiation to tumors using antibody-streptavidin conjugates followed by… 
Highly Cited
2001
Highly Cited
2001
Development and Characterization of a Series of Soluble Tetrameric and Monomeric Streptavidin Muteins with Differential Biotin Binding Affinities*
The strong biotin-streptavidin interaction limits the application of streptavidin as a reversible affinity matrix for… 
Highly Cited
1999
Highly Cited
1999
Temperature control of biotin binding and release with A streptavidin-poly(N-isopropylacrylamide) site-specific conjugate.
The many laboratory and diagnostic applications utilizing streptavidin as a molecular adaptor rely on its high affinity and… 
Highly Cited
1995
Highly Cited
1995
Intersubunit contacts made by tryptophan 120 with biotin are essential for both strong biotin binding and biotin-induced tighter subunit association of streptavidin.
In natural streptavidin, tryptophan 120 of each subunit makes contacts with the biotin bound by an adjacent subunit through the… 
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