Wen-Yih Chen

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Protein misfolding and aggregation cause a large number of neurodegenerative diseases in humans due to (i) gain of function as observed in Alzheimer's disease, Huntington's disease, Parkinson's disease, and Prion's disease or (ii) loss of function as observed in cystic fibrosis and alpha1-antitrypsin deficiency. These misfolded proteins could either lead to(More)
In this letter, a real-time approach to identify the various DNA molecules hybridized of the integrated micro-fluid with the simplest manufactured guided-mode resonance (GMR) sensor is presented. By monitoring the resonant peak wavelength shift of GMR biosensor, the DNA hybridization experiment can be recognized and clarified. The biosensor exhibited(More)
Recent developments in aptamers have led to their widespread use in analytical and diagnostic applications, particularly for biosensing. Previous studies have combined aptamers as ligands with various sensors for numerous applications. However, merging the aptamer developments with guided mode resonance (GMR) devices has not been attempted. This study(More)
Biotin is an essential vitamin which plays an important role for maintaining normal physiological function. A rapid, sensitive, and simple method is necessary to monitor the biotin level. Here, we reported a replacement assay for the detection of biotin using a replaceable liposomal aptamer. Replacement assay is a competitive assay where a sample analyte(More)
Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin-2 (Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of this study was to introduce a computational simulation approach to screen aptamers with high binding ability for Ang2. We carried out computational simulations of(More)
In this study, a polarization-control setup for intensity-resolved guided mode resonance sensors is proposed and demonstrated experimentally. The experimental results are in good agreement with the simulation data based on rigorous coupled wave approach calculations. The proposed intensity-resolved measurement setup transfers polarization ellipses, which(More)
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