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bimakalim

Known as: 4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (7)

Antihypertensive AgentsBenzopyransBronchodilator AgentsCardiotonic Agents

Narrower (2)

EMD 52692SR 44866

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Dose-Related Shortening of Ventricular Tachycardia Cycle Length After Administration of the KATP Channel Opener Bimakalim in a 4-Day-Old Chronic Infarct Anesthetized Pig Model
Potassium channel openers are known to act on potassium ATP-dependent channels in cardiac tissue. Such agents may exacerbate… 
2006
2006
KATP channel openers of the benzopyran type reach their binding site via the cytosol
ATP‐sensitive K+ (KATP) channels are composed of pore‐forming subunits (Kir6.x) and of sulphonylurea receptors (SUR). Both… 
Highly Cited
2003
Highly Cited
2003
14,15-Epoxyeicosa-5(Z)-Enoic-mSI: A 14,15- and 5,6-EET Antagonist in Bovine Coronary Arteries
Abstract—Endothelium-dependent hyperpolarizations and relaxation of vascular smooth muscle induced by acetylcholine and… 
Highly Cited
2002
Highly Cited
2002
Isoflurane-induced Facilitation of the Cardiac Sarcolemmal KATP Channel
Background Volatile anesthetics have cardioprotective effects that mimic ischemic preconditioning, including the involvement of… 
1998
1998
Effects of vasodilators and perfusion pressure on coronary flow and simultaneous release of nitric oxide from guinea pig isolated hearts.
Review
1998
Review
1998
Toward the heart of ischemic preconditioning.
1994
1994
Effect of bimakalim (EMD 52692), an opener of ATP sensitive potassium channels, on infarct size, coronary blood flow, regional wall function, and oxygen consumption in swine.
OBJECTIVE The aim was to assess whether bimakalim, an opener of ATP sensitive potassium channels, can reduce infarct size in… 
1994
1994
Reduction in Myocardial Infarct Size by the New Potassium Channel Opener Bimakalim
Summary: We examined the effect of a new potassium channel opener, bimakalim, on myocardial infarct size (IS) in dogs. Barbital… 
1994
1994
The lack of bronchodilator effect and the short-term safety of cumulative single doses of an inhaled potassium channel opener (bimakalim) in adult patients with mild to moderate bronchial asthma.
The aim of this study was to assess the bronchodilator effect and short-term safety of cumulative single doses of inhaled… 
1993
1993
Potent Hemodynamic Effects of Bimakalim, a New Potassium Channel Opener, in Humans
The cardiac hemodynamic effects of bimakalim, a new potassium channel opener, were evaluated in 12 normal volunteers by… 
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